Cited 7 times in
Impact of preoperative renal replacement therapy on the clinical outcome of heart transplant patients
DC Field | Value | Language |
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dc.contributor.author | 강석민 | - |
dc.contributor.author | 오재원 | - |
dc.date.accessioned | 2022-09-14T01:23:30Z | - |
dc.date.available | 2022-09-14T01:23:30Z | - |
dc.date.issued | 2021-06 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190434 | - |
dc.description.abstract | Renal dysfunction is considered as a relative contraindication for heart transplantation (HTx). However, in the real world setting, many patients with advanced heart failure (HF) experience worsening of renal function and some even require renal replacement therapy (RRT) by the time they undergo HTx. We aimed to investigate the prognosis and clinical outcomes of HTx patients who required RRT during the perioperative period. The Korean Organ Transplant Registry (KOTRY) is a nationwide organ transplant registry in Korea. A total of 501 HTx patients had been prospectively enrolled in the KOTRY registry during 2014-2018. Among the 501 patients, 13 underwent combined heart and kidney transplantation (HKTx). The 488 patients who underwent isolated HTx were grouped according to their pre- and postoperative RRT status. The primary outcome was progression to dialysis-dependent end-stage renal disease (ESRD) after HTx. The secondary outcome was all-cause mortality after HTx. The median follow-up was 22 months (9-39 months). Patients who needed preoperative RRT but were free from postoperative RRT showed comparable overall survival and renal outcome to patients who were free from both pre- and postoperative RRT. In multivariable analysis, preoperative RRT was not associated with progression to ESRD or all-cause mortality after HTx; however, postoperative RRT was a significant predictor for both progression to ESRD and all-cause mortality after HTx. Preoperative creatinine or estimated glomerular filtration rate (eGFR) were not predictive of progression to ESRD after HTx. The present analysis suggests that preoperative RRT requirement does not indicate irreversible renal dysfunction in patients waiting for HTx. However, postoperative RRT was associated with progression to ESRD and mortality after HTx. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Acute Kidney Injury / metabolism | - |
dc.subject.MESH | Acute Kidney Injury / pathology* | - |
dc.subject.MESH | Acute Kidney Injury / therapy | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Creatinine / metabolism | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glomerular Filtration Rate / physiology | - |
dc.subject.MESH | Heart Failure / complications | - |
dc.subject.MESH | Heart Failure / metabolism | - |
dc.subject.MESH | Heart Transplantation / adverse effects* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney / metabolism | - |
dc.subject.MESH | Kidney / pathology* | - |
dc.subject.MESH | Kidney Failure, Chronic / metabolism | - |
dc.subject.MESH | Kidney Failure, Chronic / pathology* | - |
dc.subject.MESH | Kidney Failure, Chronic / therapy | - |
dc.subject.MESH | Kidney Transplantation / methods | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Preoperative Care | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Renal Dialysis / methods | - |
dc.subject.MESH | Renal Replacement Therapy / methods | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Transplants / pathology | - |
dc.title | Impact of preoperative renal replacement therapy on the clinical outcome of heart transplant patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Darae Kim | - |
dc.contributor.googleauthor | Jin-Oh Choi | - |
dc.contributor.googleauthor | Yang Hyun Cho | - |
dc.contributor.googleauthor | Kiick Sung | - |
dc.contributor.googleauthor | Jaewon Oh | - |
dc.contributor.googleauthor | Hyun Jai Cho | - |
dc.contributor.googleauthor | Sung-Ho Jung | - |
dc.contributor.googleauthor | Hae-Young Lee | - |
dc.contributor.googleauthor | Jin Joo Park | - |
dc.contributor.googleauthor | Dong-Ju Choi | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.contributor.googleauthor | Jae-Joong Kim | - |
dc.contributor.googleauthor | Eun-Seok Jeon | - |
dc.identifier.doi | 10.1038/s41598-021-92800-0 | - |
dc.contributor.localId | A00037 | - |
dc.contributor.localId | A02395 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 34183719 | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.affiliatedAuthor | 강석민 | - |
dc.contributor.affiliatedAuthor | 오재원 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 13398 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.11(1) : 13398, 2021-06 | - |
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