Cited 28 times in
Biomaterials and strategies for repairing spinal cord lesions
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 하윤 | - |
dc.date.accessioned | 2022-09-14T01:18:46Z | - |
dc.date.available | 2022-09-14T01:18:46Z | - |
dc.date.issued | 2021-03 | - |
dc.identifier.issn | 0197-0186 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190389 | - |
dc.description.abstract | Spinal cord injury (SCI) causes intractable disease and leads to inevitable physical, financial, and psychological burdens on patients and their families. SCI is commonly divided into primary and secondary injury. Primary injury occurs upon direct impact to the spinal cord, which leads to cell necrosis, axon disruption, and vascular loss. This triggers pathophysiological secondary injury, which has several phases: acute, subacute, intermediate, and chronic. These phases are dependent on post-injury time and pathophysiology and have various causes, such as the infiltration of inflammatory cells and release of cytokines that can act as a barrier to neural regeneration. Another unique feature of SCI is the glial scar produced from the reactive proliferation of astrocytes, which acts as a barrier to axonal regeneration. Interdisciplinary research is investigating the use of biomaterials and tissue-engineered fabrication to overcome SCI. In this review, we discuss representative biomaterials, including natural and synthetic polymers and nanomaterials. In addition, we describe several strategies to repair spinal cord injuries, such as fabrication and the delivery of therapeutic biocomponents. These biomaterials and strategies may offer beneficial information to enhance the repair of spinal cord lesions. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Pergamon Press | - |
dc.relation.isPartOf | NEUROCHEMISTRY INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Astrocytes / drug effects | - |
dc.subject.MESH | Astrocytes / metabolism | - |
dc.subject.MESH | Astrocytes / pathology | - |
dc.subject.MESH | Axons / drug effects | - |
dc.subject.MESH | Axons / metabolism | - |
dc.subject.MESH | Axons / pathology | - |
dc.subject.MESH | Biocompatible Materials / administration & dosage* | - |
dc.subject.MESH | Biocompatible Materials / metabolism | - |
dc.subject.MESH | Chitosan / administration & dosage | - |
dc.subject.MESH | Chitosan / metabolism | - |
dc.subject.MESH | Collagen / administration & dosage | - |
dc.subject.MESH | Collagen / metabolism | - |
dc.subject.MESH | Gliosis / drug therapy | - |
dc.subject.MESH | Gliosis / metabolism | - |
dc.subject.MESH | Gliosis / pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyaluronic Acid / administration & dosage | - |
dc.subject.MESH | Hyaluronic Acid / metabolism | - |
dc.subject.MESH | Nanostructures / administration & dosage* | - |
dc.subject.MESH | Nerve Regeneration / drug effects | - |
dc.subject.MESH | Nerve Regeneration / physiology* | - |
dc.subject.MESH | Spinal Cord Injuries / metabolism | - |
dc.subject.MESH | Spinal Cord Injuries / pathology | - |
dc.subject.MESH | Spinal Cord Injuries / therapy* | - |
dc.title | Biomaterials and strategies for repairing spinal cord lesions | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학교실) | - |
dc.contributor.googleauthor | Hun-Jin Jeong | - |
dc.contributor.googleauthor | Yeomin Yun | - |
dc.contributor.googleauthor | Seung-Jae Lee | - |
dc.contributor.googleauthor | Yoon Ha | - |
dc.contributor.googleauthor | So-Jung Gwak | - |
dc.identifier.doi | 10.1016/j.neuint.2021.104973 | - |
dc.contributor.localId | A04255 | - |
dc.contributor.localId | A04116 | - |
dc.relation.journalcode | J02326 | - |
dc.identifier.eissn | 1872-9754 | - |
dc.identifier.pmid | 33497713 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S019701862100019X | - |
dc.subject.keyword | Biomaterials | - |
dc.subject.keyword | Natural polymer | - |
dc.subject.keyword | Nerve regeneration | - |
dc.subject.keyword | Spinal cord injury | - |
dc.subject.keyword | Synthetic polymer | - |
dc.contributor.alternativeName | Ha, Yoon | - |
dc.contributor.affiliatedAuthor | 하윤 | - |
dc.citation.volume | 144 | - |
dc.citation.startPage | 104973 | - |
dc.identifier.bibliographicCitation | NEUROCHEMISTRY INTERNATIONAL, Vol.144 : 104973, 2021-03 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.