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Technology of deep brain stimulation: current status and future directions

 Joachim K Krauss  ;  Nir Lipsman  ;  Tipu Aziz  ;  Alexandre Boutet  ;  Peter Brown  ;  Jin Woo Chang  ;  Benjamin Davidson  ;  Warren M Grill  ;  Marwan I Hariz  ;  Andreas Horn  ;  Michael Schulder  ;  Antonios Mammis  ;  Peter A Tass  ;  Jens Volkmann  ;  Andres M Lozano 
 NATURE REVIEWS NEUROLOGY, Vol.17(2) : 75-87, 2021-02 
Journal Title
NATURE REVIEWS NEUROLOGY(Nature Reviews. Neurology)
Issue Date
Biomedical Technology / instrumentation ; Biomedical Technology / methods* ; Biomedical Technology / trends* ; Deep Brain Stimulation / instrumentation ; Deep Brain Stimulation / methods* ; Deep Brain Stimulation / trends* ; Depressive Disorder, Major / physiopathology ; Depressive Disorder, Major / surgery ; Dystonic Disorders / physiopathology ; Dystonic Disorders / surgery ; Essential Tremor / physiopathology ; Essential Tremor / surgery ; Forecasting ; Humans ; Implantable Neurostimulators / trends* ; Parkinson Disease / physiopathology ; Parkinson Disease / surgery
Deep brain stimulation (DBS) is a neurosurgical procedure that allows targeted circuit-based neuromodulation. DBS is a standard of care in Parkinson disease, essential tremor and dystonia, and is also under active investigation for other conditions linked to pathological circuitry, including major depressive disorder and Alzheimer disease. Modern DBS systems, borrowed from the cardiac field, consist of an intracranial electrode, an extension wire and a pulse generator, and have evolved slowly over the past two decades. Advances in engineering and imaging along with an improved understanding of brain disorders are poised to reshape how DBS is viewed and delivered to patients. Breakthroughs in electrode and battery designs, stimulation paradigms, closed-loop and on-demand stimulation, and sensing technologies are expected to enhance the efficacy and tolerability of DBS. In this Review, we provide a comprehensive overview of the technical development of DBS, from its origins to its future. Understanding the evolution of DBS technology helps put the currently available systems in perspective and allows us to predict the next major technological advances and hurdles in the field.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
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