Cited 10 times in
Romosozumab in Postmenopausal Korean Women with Osteoporosis: A Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study
DC Field | Value | Language |
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dc.contributor.author | 임승길 | - |
dc.date.accessioned | 2022-09-14T01:13:54Z | - |
dc.date.available | 2022-09-14T01:13:54Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190357 | - |
dc.description.abstract | Background: This phase 3 study evaluated the efficacy and safety of 6-month treatment with romosozumab in Korean postmenopausal women with osteoporosis. Methods: Sixty-seven postmenopausal women with osteoporosis (bone mineral density [BMD] T-scores ≤-2.5 at the lumbar spine, total hip, or femoral neck) were randomized (1:1) to receive monthly subcutaneous injections of romosozumab (210 mg; n=34) or placebo (n=33) for 6 months. Results: At month 6, the difference in the least square (LS) mean percent change from baseline in lumbar spine BMD (primary efficacy endpoint) between the romosozumab (9.5%) and placebo (-0.1%) groups was significant (9.6%; 95% confidence interval, 7.6 to 11.5; P<0.001). The difference in the LS mean percent change from baseline was also significant for total hip and femoral neck BMD (secondary efficacy endpoints). After treatment with romosozumab, the percent change from baseline in procollagen type 1 N-terminal propeptide transiently increased at months 1 and 3, while that in C-terminal telopeptide of type 1 collagen showed a sustained decrease. No events of cancer, hypocalcemia, injection site reaction, positively adjudicated atypical femoral fracture or osteonecrosis of the jaw, or positively adjudicated serious cardiovascular adverse events were observed. At month 9, 17.6% and 2.9% of patients in the romosozumab group developed binding and neutralizing antibodies, respectively. Conclusion: Treatment with romosozumab for 6 months was well tolerated and significantly increased lumbar spine, total hip, and femoral neck BMD compared with placebo in Korean postmenopausal women with osteoporosis (ClinicalTrials.gov identifier NCT02791516). | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Endocrine Society | - |
dc.relation.isPartOf | Endocrinology and Metabolism(대한내분비학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Antibodies, Monoclonal | - |
dc.subject.MESH | Bone Density | - |
dc.subject.MESH | Bone Density Conservation Agents* / adverse effects | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Osteoporosis* / chemically induced | - |
dc.subject.MESH | Postmenopause | - |
dc.subject.MESH | Republic of Korea | - |
dc.title | Romosozumab in Postmenopausal Korean Women with Osteoporosis: A Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Ki-Hyun Baek | - |
dc.contributor.googleauthor | Yoon-Sok Chung | - |
dc.contributor.googleauthor | Jung-Min Koh | - |
dc.contributor.googleauthor | In Joo Kim | - |
dc.contributor.googleauthor | Kyoung Min Kim | - |
dc.contributor.googleauthor | Yong-Ki Min | - |
dc.contributor.googleauthor | Ki Deok Park | - |
dc.contributor.googleauthor | Rajani Dinavahi | - |
dc.contributor.googleauthor | Judy Maddox | - |
dc.contributor.googleauthor | Wenjing Yang | - |
dc.contributor.googleauthor | Sooa Kim | - |
dc.contributor.googleauthor | Sang Jin Lee | - |
dc.contributor.googleauthor | Hyungjin Cho | - |
dc.contributor.googleauthor | Sung-Kil Lim | - |
dc.identifier.doi | 10.3803/EnM.2020.848 | - |
dc.contributor.localId | A03375 | - |
dc.relation.journalcode | J00773 | - |
dc.identifier.eissn | 2093-5978 | - |
dc.identifier.pmid | 33677928 | - |
dc.subject.keyword | Bone density | - |
dc.subject.keyword | Bone turnover markers | - |
dc.subject.keyword | Korea | - |
dc.subject.keyword | Randomized controlled trial | - |
dc.subject.keyword | Romosozumab | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.affiliatedAuthor | 임승길 | - |
dc.citation.volume | 36 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 60 | - |
dc.citation.endPage | 69 | - |
dc.identifier.bibliographicCitation | Endocrinology and Metabolism (대한내분비학회지), Vol.36(1) : 60-69, 2021-02 | - |
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