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Effect of ambulatory blood pressure monitoring guided antihypertensive treatment on renal progression in patients with chronic kidney disease: a randomized comparative study

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dc.contributor.author유태현-
dc.date.accessioned2022-09-14T01:13:19Z-
dc.date.available2022-09-14T01:13:19Z-
dc.date.issued2021-02-
dc.identifier.issn0263-6352-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/190349-
dc.description.abstractObjectives: Adequate blood pressure (BP) control is pivotal for managing chronic kidney disease (CKD). The optimal approach for monitoring BP to delay CKD progression is not yet clear. Methods: Patients with hypertension and CKD stage 3-4 were randomized into ambulatory blood pressure monitoring (ABPM) or office BP groups. All patients had ABPM at baseline and 18 months, and the ABPM group additionally underwent ABPM at 3 and 6 months. Each ABPM result was notified only for the ABPM group. The BP target was daytime ABP less than 135/85 mmHg for the ABPM group and office BP less than 140/90 mmHg for the office BP group. The primary outcome was decrease in estimated glomerular filtration rate (eGFR) during 18 months. Results: A total of 146 patients were randomized into the ABPM (n = 69) and office BP groups (n = 77). Although office BP was comparable in the two groups at baseline, daytime ABP was higher in the ABPM group (median 140 vs. 132 mmHg). Initial eGFR was 35.7 ± 12.5 ml/min per 1.73 m2 in the ABPM group and 34.6 ± 12.0 ml/min per 1.73 m2 in the office BP group. eGFR change was -5.5 [95% confidence interval (95% CI) -7.7 to -3.4] ml/min per 1.73 m2 in the ABPM group and -5.0 (95% CI -6.9 to -3.0) ml/min per 1.73 m2 in the office BP group (P = 0.704). Renal events occurred in 10 patients (15.6%) from the ABPM group and five (7.1%) from the office BP group (P = 0.120). Conclusion: The present study did not show a beneficial effect of ABPM for controlling hypertension in CKD compared with conventional office BP monitoring in terms of renal outcomes. Trial registration: ClinicalTrials.gov NCT02417571.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfJOURNAL OF HYPERTENSION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAntihypertensive Agents / therapeutic use-
dc.subject.MESHBlood Pressure-
dc.subject.MESHBlood Pressure Monitoring, Ambulatory-
dc.subject.MESHHumans-
dc.subject.MESHHypertension* / complications-
dc.subject.MESHHypertension* / drug therapy-
dc.subject.MESHRenal Insufficiency, Chronic* / complications-
dc.subject.MESHRenal Insufficiency, Chronic* / drug therapy-
dc.titleEffect of ambulatory blood pressure monitoring guided antihypertensive treatment on renal progression in patients with chronic kidney disease: a randomized comparative study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYunmi Kim-
dc.contributor.googleauthorJayoun Kim-
dc.contributor.googleauthorSung Woo Lee-
dc.contributor.googleauthorSuah Sung-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorKyu-Beck Lee-
dc.contributor.googleauthorYoung-Hwan Hwang-
dc.contributor.googleauthorTaehee Kim-
dc.contributor.googleauthorSun Woo Kang-
dc.contributor.googleauthorYeong Hoon Kim-
dc.contributor.googleauthorKook-Hwan Oh-
dc.identifier.doi10.1097/HJH.0000000000002624-
dc.contributor.localIdA02526-
dc.relation.journalcodeJ01448-
dc.identifier.eissn1473-5598-
dc.identifier.pmid33031169-
dc.identifier.urlhttps://journals.lww.com/jhypertension/Fulltext/2021/02000/Effect_of_ambulatory_blood_pressure_monitoring.19.aspx-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.affiliatedAuthor유태현-
dc.citation.volume39-
dc.citation.number2-
dc.citation.startPage325-
dc.citation.endPage332-
dc.identifier.bibliographicCitationJOURNAL OF HYPERTENSION, Vol.39(2) : 325-332, 2021-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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