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Incidence of cardiovascular events and mortality in Korean patients with chronic kidney disease

 Hyunjin Ryu  ;  Jayoun Kim  ;  Eunjeong Kang  ;  Yeji Hong  ;  Dong-Wan Chae  ;  Kyu Hun Choi  ;  Seung Hyeok Han  ;  Tae Hyun Yoo  ;  Kyubeck Lee  ;  Yong-Soo Kim  ;  Wookyung Chung  ;  Yun Kyu Oh  ;  Soo Wan Kim  ;  Yeong Hoon Kim  ;  Su Ah Sung  ;  Joongyub Lee  ;  Sue K Park  ;  Curie Ahn  ;  Kook-Hwan Oh 
 SCIENTIFIC REPORTS, Vol.11(1) : 1131, 2021-01 
Journal Title
Issue Date
Adult ; Aged ; Cardiovascular Diseases / complications* ; Cardiovascular Diseases / epidemiology* ; Cardiovascular Diseases / mortality ; Cause of Death ; Comorbidity ; Diabetes Complications ; Female ; Humans ; Incidence ; Longitudinal Studies ; Male ; Middle Aged ; Proportional Hazards Models ; Prospective Studies ; Renal Insufficiency, Chronic / complications* ; Republic of Korea / epidemiology ; Risk Factors ; Young Adult
Few studies have investigated the incidence of cardiovascular disease (CVD) in the Asian chronic kidney disease (CKD) population. This study assessed the incidence of CVD, death, and a composite outcome of CVD and death in a prospective Korean predialysis CKD cohort. From a total of 2179 patients, incidence rates were analyzed, and competing risk analyses were conducted according to CKD stage. Additionally, incidence was compared to the general population. During a median 4.1 years of follow-up, the incidence of CVD, all-cause death, and the composite outcome was 17.2, 9.6, and 24.5 per 1000 person-years, respectively. These values were higher in diabetic vs. non-diabetic subjects (P < 0.001). For all outcomes, incidence rates increased with increasing CKD stage (CVD, P = 0.001; death, P < 0.001; and composite, P < 0.001). Additionally, CKD stage G4 [hazard ratio (HR) 2.8, P = 0.008] and G5 (HR 5.0, P < 0.001) were significant risk factors for the composite outcome compared to stage G1 after adjustment. Compared to the general population, the total cohort population (stages G1-G5) showed significantly higher risk of CVD (HR 2.4, P < 0.001) and the composite outcome (HR 1.7, P < 0.001). The results clearly demonstrate that CKD is a risk factor for CVD in an Asian population.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
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