Cited 23 times in
Local Stabilization of Hypoxia-Inducible Factor-1α Controls Intestinal Inflammation via Enhanced Gut Barrier Function and Immune Regulation
DC Field | Value | Language |
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dc.contributor.author | 천재희 | - |
dc.date.accessioned | 2022-09-14T01:11:04Z | - |
dc.date.available | 2022-09-14T01:11:04Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190327 | - |
dc.description.abstract | Intestinal epithelial cells are adapted in mucosal hypoxia and hypoxia-inducible factors in these cells can fortify barrier integrity to support mucosal tissue healing. Here we investigated whether hypoxia-related pathways could be proposed as potential therapeutic targets for inflammatory bowel disease. We developed a novel hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor, CG-598 which stabilized HIF-1α in the gut tissue. Treatment of CG-598 did not affect extra-intestinal organs or cause any significant adverse effects such as erythropoiesis. In the experimental murine colitis model, CG-598 ameliorated intestinal inflammation with reduction of inflammatory lesions and pro-inflammatory cytokines. CG-598 treatment fortified barrier function by increasing the expression of intestinal trefoil factor, CD73, E-cadherin and mucin. Also, IL-10 and IL-22 were induced from lamina propria CD4+ T-cells. The effectiveness of CG-598 was comparable to other immunosuppressive therapeutics such as TNF-blockers or JAK inhibitors. These results suggest that CG-598 could be a promising therapeutic candidate to treat inflammatory bowel disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Frontiers Research Foundation | - |
dc.relation.isPartOf | FRONTIERS IN IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Caco-2 Cells | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Colitis / drug therapy | - |
dc.subject.MESH | Colitis / immunology | - |
dc.subject.MESH | Colitis / metabolism | - |
dc.subject.MESH | Cytokines / immunology | - |
dc.subject.MESH | Cytokines / metabolism | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | HCT116 Cells | - |
dc.subject.MESH | HeLa Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypoxia / drug therapy | - |
dc.subject.MESH | Hypoxia / immunology | - |
dc.subject.MESH | Hypoxia / metabolism | - |
dc.subject.MESH | Hypoxia-Inducible Factor 1, alpha Subunit / immunology* | - |
dc.subject.MESH | Hypoxia-Inducible Factor 1, alpha Subunit / metabolism* | - |
dc.subject.MESH | Inflammation / immunology* | - |
dc.subject.MESH | Inflammation / metabolism* | - |
dc.subject.MESH | Inflammatory Bowel Diseases / drug therapy | - |
dc.subject.MESH | Inflammatory Bowel Diseases / immunology | - |
dc.subject.MESH | Inflammatory Bowel Diseases / metabolism | - |
dc.subject.MESH | Intestinal Mucosa / drug effects | - |
dc.subject.MESH | Intestinal Mucosa / immunology* | - |
dc.subject.MESH | Intestinal Mucosa / metabolism* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | Prolyl-Hydroxylase Inhibitors / pharmacology | - |
dc.subject.MESH | Trefoil Factor-3 / immunology | - |
dc.subject.MESH | Trefoil Factor-3 / metabolism | - |
dc.title | Local Stabilization of Hypoxia-Inducible Factor-1α Controls Intestinal Inflammation via Enhanced Gut Barrier Function and Immune Regulation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Young-In Kim | - |
dc.contributor.googleauthor | Eun-Je Yi | - |
dc.contributor.googleauthor | Young-Dae Kim | - |
dc.contributor.googleauthor | A Reum Lee | - |
dc.contributor.googleauthor | Jiwoung Chung | - |
dc.contributor.googleauthor | Hae Chan Ha | - |
dc.contributor.googleauthor | Joong Myung Cho | - |
dc.contributor.googleauthor | Seong-Ryeol Kim | - |
dc.contributor.googleauthor | Hyun-Jeong Ko | - |
dc.contributor.googleauthor | Jae-Hee Cheon | - |
dc.contributor.googleauthor | Yong Rae Hong | - |
dc.contributor.googleauthor | Sun-Young Chang | - |
dc.identifier.doi | 10.3389/fimmu.2020.609689 | - |
dc.contributor.localId | A04030 | - |
dc.relation.journalcode | J03075 | - |
dc.identifier.eissn | 1664-3224 | - |
dc.identifier.pmid | 33519819 | - |
dc.subject.keyword | gut barrier | - |
dc.subject.keyword | hypoxia-inducible factor | - |
dc.subject.keyword | immune regulation | - |
dc.subject.keyword | inflammatory bowel disease | - |
dc.subject.keyword | prolyl hydroxylase inhibitor | - |
dc.contributor.alternativeName | Cheon, Jae Hee | - |
dc.contributor.affiliatedAuthor | 천재희 | - |
dc.citation.volume | 11 | - |
dc.citation.startPage | 609689 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN IMMUNOLOGY, Vol.11 : 609689, 2021-01 | - |
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