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Heat shock protein signaling in brain ischemia and injury

Authors
 Jong Youl Kim  ;  Ji Won Kim  ;  Midori A Yenari 
Citation
 NEUROSCIENCE LETTERS, Vol.715 : 134642, 2020-01 
Journal Title
NEUROSCIENCE LETTERS
ISSN
 0304-3940 
Issue Date
2020-01
MeSH
Animals ; Apoptosis / physiology* ; Brain Injuries / physiopathology* ; Brain Ischemia / physiopathology* ; HSP70 Heat-Shock Proteins / physiology* ; Humans ; Neuroprotection / physiology*
Keywords
Heat shock protein 70 ; Cerebral ischemic stroke ; Traumatic brain injury ; Neuroprotection ; Pharmacological induction
Abstract
Heat shock proteins (HSPs) are chaperones that catalyze the refolding of denatured proteins. In addition to their ability to prevent protein denaturation and aggregation, the HSPs have also been shown to modulate many signaling pathways. Among HSPs, the inducible 70 kDa HSP (HSP70) has especially been shown to improve neurological outcome in experimental models of brain ischemia and injury. HSP70 can modulate various aspects of the programmed cell death pathways and inflammation. This review will focus on potential mechanisms of the neuroprotective effects of HSP70 in stroke and brain trauma models. We also comment on potential ways in which HSP70 could be translated into clinical therapies.
Files in This Item:
T9992020536.pdf Download
DOI
10.1016/j.neulet.2019.134642
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Youl(김종열) ORCID logo https://orcid.org/0000-0002-8340-2894
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190311
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