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Beam angle optimization using angular dependency of range variation assessed via water equivalent path length (WEPL) calculation for head and neck proton therapy

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dc.contributor.author김지훈-
dc.date.accessioned2022-09-06T06:43:45Z-
dc.date.available2022-09-06T06:43:45Z-
dc.date.issued2020-01-
dc.identifier.issn1120-1797-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/190295-
dc.description.abstractPurpose: To investigate angular sensitivity of proton range variation due to anatomic change in patients and patient setup error via water equivalent path length (WEPL) calculations. Methods: Proton range was estimated by calculating WEPL to the distal edge of target volume using planning CT (pCT) and weekly scatter-corrected cone-beam CT (CBCT) images of 11 head and neck patients. Range variation was estimated as the difference between the distal WEPLs calculated on pCT and scatter-corrected CBCT (cCBCT). This WEPL analysis was performed every five degrees ipsilaterally to the target. Statistics of the distal WEPL difference were calculated over the distal area to compare between different beam angles. Physician-defined contours were used for the WEPL calculation on both pCT and cCBCT, not considering local deformation of target volume. It was also tested if a couch kick (10 degrees) can mitigate the range variation due to anatomic change and patient setup error. Results: For most of the patients considered, median, 75% quantile, and 95% quantile of the distal WEPL difference were largest for posterior oblique angles, indicating a higher chance of overdosing normal tissues at distal edge with these angles. Using a couch kick resulted in decrease in the WEPL difference for some posterior oblique angles. Conclusions: It was demonstrated that the WEPL change has angular dependency for the cohort of head and neck cancer patients. Selecting beam configuration robust to anatomic change in patient and patient setup error may improve the treatment outcome of head and neck proton therapy.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherIstituti Editoriali e Poligrafici Internazionali-
dc.relation.isPartOfPHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAlgorithms-
dc.subject.MESHCone-Beam Computed Tomography-
dc.subject.MESHHead and Neck Neoplasms / radiotherapy*-
dc.subject.MESHHumans-
dc.subject.MESHProton Therapy*-
dc.subject.MESHProtons-
dc.subject.MESHRadiometry-
dc.subject.MESHRadiotherapy Dosage-
dc.subject.MESHRadiotherapy Planning, Computer-Assisted-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTomography, X-Ray Computed*-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHWater / chemistry*-
dc.titleBeam angle optimization using angular dependency of range variation assessed via water equivalent path length (WEPL) calculation for head and neck proton therapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorJihun Kim-
dc.contributor.googleauthorYang-Kyun Park-
dc.contributor.googleauthorGregory Sharp-
dc.contributor.googleauthorPaul Busse-
dc.contributor.googleauthorBrian Winey-
dc.identifier.doi10.1016/j.ejmp.2019.11.021-
dc.contributor.localIdA05823-
dc.relation.journalcodeJ02892-
dc.identifier.eissn1724-191X-
dc.identifier.pmid31812726-
dc.subject.keywordWater equivalent path length-
dc.subject.keywordAngular dependency-
dc.subject.keywordProton therapy-
dc.subject.keywordAnatomic change-
dc.subject.keywordPatient setup error-
dc.subject.keywordCone-beam CT-
dc.subject.keywordScatter correction-
dc.contributor.alternativeNameKim, Jihun-
dc.contributor.affiliatedAuthor김지훈-
dc.citation.volume69-
dc.citation.startPage19-
dc.citation.endPage27-
dc.identifier.bibliographicCitationPHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, Vol.69 : 19-27, 2020-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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