Cited 3 times in

Different association between renal dysfunction and clinical outcomes according to the presence of diabetes in patients undergoing endovascular treatment for peripheral artery disease

DC Field Value Language
dc.contributor.author고영국-
dc.contributor.author민필기-
dc.contributor.author최동훈-
dc.date.accessioned2022-09-06T06:43:35Z-
dc.date.available2022-09-06T06:43:35Z-
dc.date.issued2020-01-
dc.identifier.issn0741-5214-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/190294-
dc.description.abstractObjective: Although chronic kidney disease (CKD) and diabetes are important prognostic factors in patients with peripheral artery disease, there are limited data regarding the outcomes of endovascular treatment (EVT) according to the severity of CKD, especially in the presence of diabetes. This study sought to compare clinical outcomes of lower limb EVT between patients with and patients without CKD according to the presence of diabetes. Methods: Patients were enrolled from the Korean multicenter EVT registry and were divided according to the presence of diabetes, then further stratified by CKD (estimated glomerular filtration rate <60 mL/min/1.73 m(2)). The primary outcome was major adverse limb events (MALEs; a composite of reintervention for target limb, reintervention for target vessel, and unplanned major amputation) at 2 years. Results: A total of 3045 patients were eligible for analysis: 1277 nondiabetic patients (944 without CKD, 333 with CKD) and 1768 diabetic patients (951 without CKD, 817 with CKD). CKD was associated with a significantly increased risk of MALEs after EVT in diabetic patients (14.4% vs 9.9%; adjusted hazard ratio, 1.60; 95% confidence interval, 1.28-2.01; P < .001) but not in nondiabetic patients (7.6% vs 9.7%; adjusted hazard ratio, 0.78; 95% confidence interval, 0.53-1.14; P = .203; interaction P = .018). In analysis stratified by the severity of CKD among diabetic patients, end-stage renal disease was significantly associated with an increased risk of MALE. Conclusions: CKD was associated with a significantly higher risk of MALEs after EVT in diabetic patients but not in nondiabetic patients. The increased risk of MALEs was mainly driven by patients with end-stage renal disease.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfJOURNAL OF VASCULAR SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHAmputation-
dc.subject.MESHDiabetes Mellitus / diagnosis-
dc.subject.MESHDiabetes Mellitus / epidemiology*-
dc.subject.MESHEndovascular Procedures* / adverse effects-
dc.subject.MESHFemale-
dc.subject.MESHGlomerular Filtration Rate*-
dc.subject.MESHHumans-
dc.subject.MESHKidney / physiopathology*-
dc.subject.MESHLimb Salvage-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPeripheral Arterial Disease / diagnostic imaging-
dc.subject.MESHPeripheral Arterial Disease / epidemiology-
dc.subject.MESHPeripheral Arterial Disease / physiopathology-
dc.subject.MESHPeripheral Arterial Disease / therapy*-
dc.subject.MESHRegistries-
dc.subject.MESHRenal Insufficiency, Chronic / diagnosis-
dc.subject.MESHRenal Insufficiency, Chronic / epidemiology*-
dc.subject.MESHRenal Insufficiency, Chronic / physiopathology-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment-
dc.subject.MESHRisk Factors-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titleDifferent association between renal dysfunction and clinical outcomes according to the presence of diabetes in patients undergoing endovascular treatment for peripheral artery disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJihoon Kim-
dc.contributor.googleauthorTaek Kyu Park-
dc.contributor.googleauthorKi Hong Choi-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorYoung-Guk Ko-
dc.contributor.googleauthorJae-Hwan Lee-
dc.contributor.googleauthorChang-Hwan Yoon-
dc.contributor.googleauthorIn-Ho Chae-
dc.contributor.googleauthorCheol Woong Yu-
dc.contributor.googleauthorPil-Ki Min-
dc.contributor.googleauthorSeung-Whan Lee-
dc.contributor.googleauthorSang-Rok Lee-
dc.contributor.googleauthorYoon Seok Koh-
dc.contributor.googleauthorSeung-Hyuk Choi-
dc.identifier.doi10.1016/j.jvs.2019.03.071-
dc.contributor.localIdA00127-
dc.contributor.localIdA01412-
dc.contributor.localIdA04053-
dc.relation.journalcodeJ01924-
dc.identifier.eissn1097-6809-
dc.identifier.pmid31285068-
dc.subject.keywordPeripheral artery disease-
dc.subject.keywordEndovascular treatment-
dc.subject.keywordRenal dysfunction-
dc.subject.keywordDiabetes mellitus-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.affiliatedAuthor고영국-
dc.contributor.affiliatedAuthor민필기-
dc.contributor.affiliatedAuthor최동훈-
dc.citation.volume71-
dc.citation.number1-
dc.citation.startPage132-
dc.citation.endPage140.e1-
dc.identifier.bibliographicCitationJOURNAL OF VASCULAR SURGERY, Vol.71(1) : 132-140.e1, 2020-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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