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Clinical Study of Standard- vs Reduced-Dose Tacrolimus Combined With Generic Mycophenolate Mofetil in De Novo Kidney Transplantation: A Prospective Randomized Trial
DC Field | Value | Language |
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dc.contributor.author | 주만기 | - |
dc.date.accessioned | 2022-09-06T06:42:38Z | - |
dc.date.available | 2022-09-06T06:42:38Z | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 0041-1345 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190284 | - |
dc.description.abstract | Background. The lowering of calcineurin inhibitor exposure is possibly considered as the proper strategy to prevent calcineurin inhibitor-induced nephrotoxicity in kidney transplant. This clinical study was designed to compare the efficacy and tolerability of reduced-dose tacrolimus with standard-dose mycophenolate mofetil (MMF) vs standard-dose tacrolimus with reduced-dose MMF. Methods. A prospective, multicenter, open-label, randomized, and parallel-group clinical trial was conducted at 4 transplant centers in Korea. A total sample size was 108, and eligible patients were randomly assigned in a 1:1 ratio to either reduced-dose tacrolimus with standard-dose MMF (the study group) or standard-dose tacrolimus with reduced-dose MMF (the control group) for 6 months in de novo kidney transplant recipients. Graft function, the incidence of efficacy failure, and adverse events were compared. Results. The mean estimated glomerular filtration rate at 6 months post-transplantation was 69.83 +/- 16.68 mL/min/1.73 m(2) in the study group and 69.92 +/- 17.55 mL/min/1.73 m(2) in the control group (P > .05). The overall incidence of biopsy-proven acute rejection was 3.64% (n = 2) in the study group, compared to 3.77% (n = 2) in the control group (P > .05). There was no graft loss, death, or loss of follow-up in either group. Conclusion. In conclusion, the results suggest that tacrolimus minimization with standard-dose MMF provides adequate immunosuppression with proper renal function and similar rate of incidence of acute rejection compared with the regimen including standard-dose tacrolimus with reduced-dose MMF. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science Inc. | - |
dc.relation.isPartOf | TRANSPLANTATION PROCEEDINGS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Drugs, Generic | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glomerular Filtration Rate | - |
dc.subject.MESH | Graft Rejection / epidemiology | - |
dc.subject.MESH | Graft Rejection / prevention & control* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunosuppression Therapy | - |
dc.subject.MESH | Immunosuppressive Agents / administration & dosage* | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Kidney Transplantation* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mycophenolic Acid / administration & dosage* | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Tacrolimus / administration & dosage* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Clinical Study of Standard- vs Reduced-Dose Tacrolimus Combined With Generic Mycophenolate Mofetil in De Novo Kidney Transplantation: A Prospective Randomized Trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Jun Bae Bang | - |
dc.contributor.googleauthor | Chang-Kwon Oh | - |
dc.contributor.googleauthor | Man Ki Ju | - |
dc.contributor.googleauthor | Sung Joo Kim | - |
dc.contributor.googleauthor | Hee Chul Yu | - |
dc.contributor.googleauthor | Su Hyung Lee | - |
dc.identifier.doi | 10.1016/j.transproceed.2019.11.029 | - |
dc.contributor.localId | A03949 | - |
dc.relation.journalcode | J02755 | - |
dc.identifier.eissn | 1873-2623 | - |
dc.identifier.pmid | 31898939 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0041134519315040 | - |
dc.contributor.alternativeName | Joo, Man Ki | - |
dc.contributor.affiliatedAuthor | 주만기 | - |
dc.citation.volume | 52 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 133 | - |
dc.citation.endPage | 139 | - |
dc.identifier.bibliographicCitation | TRANSPLANTATION PROCEEDINGS, Vol.52(1) : 133-139, 2020-01 | - |
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