Cited 27 times in
Glutathione peroxidase-1 regulates adhesion and metastasis of triple-negative breast cancer cells via FAK signaling
DC Field | Value | Language |
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dc.contributor.author | 김남희 | - |
dc.contributor.author | 육종인 | - |
dc.date.accessioned | 2022-09-06T06:42:01Z | - |
dc.date.available | 2022-09-06T06:42:01Z | - |
dc.date.issued | 2020-01 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190272 | - |
dc.description.abstract | Triple-negative breast cancer (TNBC) cells, which do not express genes for estrogen receptor (ER), progesterone receptor (PR), and Her2/neu, develop highly aggressive and metastatic tumors resistant to chemo- and hormonal therapies. We found that expression of glutathione peroxidase-1 (Gpx1) is silenced in the non-TNBC cells but significantly maintained in the TNBC cell lines. Such Gpx1 expression plays a vital role in the metastasis of TNBC cells by regulating cell adhesion. Transcriptomic and signaling pathway analyses demonstrate that depletion of Gpxl essentially impairs cell adhesion/spreading by down-regulating FAK/c-Src activation. Mechanistically, Gpx1 interacts with FAK kinase and prevents the kinase inactivation by H2O2, not lipid hydroperoxide. As a result, depletion of Gpx1 suppresses lung metastasis of TNBC cells in vivo. Overall, our study identifies that Gpx1 is a redox safeguard of FAK kinase and its inhibition may provide an effective way to control the metastasis of deadly malignant TNBC. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | REDOX BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Movement | - |
dc.subject.MESH | Focal Adhesion Kinase 1 | - |
dc.subject.MESH | Glutathione Peroxidase* / genetics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydrogen Peroxide | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Triple Negative Breast Neoplasms* / genetics | - |
dc.title | Glutathione peroxidase-1 regulates adhesion and metastasis of triple-negative breast cancer cells via FAK signaling | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Research Institute (부설연구소) | - |
dc.contributor.googleauthor | Eunkyung Lee | - |
dc.contributor.googleauthor | Ahyoung Choi | - |
dc.contributor.googleauthor | Yukyung Jun | - |
dc.contributor.googleauthor | Namhee Kim | - |
dc.contributor.googleauthor | Jong In Yook | - |
dc.contributor.googleauthor | Soo Youl Kim | - |
dc.contributor.googleauthor | Sanghyuk Lee | - |
dc.contributor.googleauthor | Sang Won Kang | - |
dc.identifier.doi | 10.1016/j.redox.2019.101391 | - |
dc.contributor.localId | A00360 | - |
dc.contributor.localId | A02536 | - |
dc.relation.journalcode | J03622 | - |
dc.identifier.eissn | 2213-2317 | - |
dc.identifier.pmid | 31926619 | - |
dc.subject.keyword | Glutathione peroxidase | - |
dc.subject.keyword | Triple-negative breast cancer | - |
dc.subject.keyword | Metastasis | - |
dc.subject.keyword | Adhesion | - |
dc.subject.keyword | Focal adhesion kinase | - |
dc.contributor.alternativeName | Kim, Nam Hee | - |
dc.contributor.affiliatedAuthor | 김남희 | - |
dc.contributor.affiliatedAuthor | 육종인 | - |
dc.citation.volume | 29 | - |
dc.citation.startPage | 101391 | - |
dc.identifier.bibliographicCitation | REDOX BIOLOGY, Vol.29 : 101391, 2020-01 | - |
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