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Heterogeneity of Human γδ T Cells and Their Role in Cancer Immunity

DC Field Value Language
dc.contributor.author이혜원-
dc.date.accessioned2022-09-06T06:39:08Z-
dc.date.available2022-09-06T06:39:08Z-
dc.date.issued2020-02-
dc.identifier.issn1598-2629-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/190248-
dc.description.abstractThe gamma delta T cells are unconventional lymphocytes that function in both innate and adaptive immune responses against various intracellular and infectious stresses. The gamma delta T cells can be exploited as cancer-killing effector cells since.d TCRs recognize MHC-like molecules and growth factor receptors that are upregulated in cancer cells, and gamma delta T cells can differentiate into cytotoxic effector cells. However, gamma delta T cells may also promote tumor progression by secreting IL-17 or other cytokines. Therefore, it is essential to understand how the differentiation and homeostasis of gamma delta T cells are regulated and whether distinct gamma delta T cell subsets have different functions. Human gamma delta T cells are classified into V delta 2 and non-V delta 2 gamma delta T cells. The majority of Vd2 gamma delta T cells are V gamma 9 delta 2 T cells that recognize pyrophosphorylated isoprenoids generated by the dysregulated mevalonate pathway. In contrast, V delta 1 T cells expand from initially diverse TCR repertoire in patients with infectious diseases and cancers. The ligands of V delta 1 T cells are diverse and include the growth factor receptors such as endothelial protein C receptor. Both V delta 1 and V delta 2 gamma delta T cells are implicated to have immunotherapeutic potentials for cancers, but the detailed elucidation of the distinct characteristics of 2 populations will be required to enhance the immunotherapeutic potential of gamma delta T cells. Here, we summarize recent progress regarding cancer immunology of human gamma delta T cells, including their development, heterogeneity, and plasticity, the putative mechanisms underlying ligand recognition and activation, and their dual effects on tumor progression in the tumor microenvironment.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorea Society for Immunology : Korean Society of Biological Response Modifiers-
dc.relation.isPartOfIMMUNE NETWORK-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleHeterogeneity of Human γδ T Cells and Their Role in Cancer Immunity-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentHospital Medicine (입원의학과)-
dc.contributor.googleauthorHye Won Lee-
dc.contributor.googleauthorYun Shin Chung-
dc.contributor.googleauthorTae Jin Kim-
dc.identifier.doi10.4110/in.2020.20.e5-
dc.contributor.localIdA05913-
dc.relation.journalcodeJ01033-
dc.identifier.eissn2092-6685-
dc.subject.keywordT-lymphocyte subsets-
dc.subject.keywordgamma delta T cell-
dc.subject.keywordT Cell Receptors-
dc.subject.keywordgamma delta-
dc.subject.keywordTumor microenvironment-
dc.contributor.alternativeNameLee, Hye Won-
dc.contributor.affiliatedAuthor이혜원-
dc.citation.volume20-
dc.citation.number1-
dc.citation.startPagee5-
dc.identifier.bibliographicCitationIMMUNE NETWORK, Vol.20(1) : e5, 2020-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Hospital Medicine (입원의학과) > 1. Journal Papers

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