Cited 2 times in
Efficacy and Safety of a Balanced Salt Solution Versus a 0.9% Saline Infusion for the Prevention of Contrast-Induced Acute Kidney Injury After Contrast-Enhanced Computed Tomography
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 한승혁 | - |
dc.date.accessioned | 2022-09-06T06:07:13Z | - |
dc.date.available | 2022-09-06T06:07:13Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190189 | - |
dc.description.abstract | Rationale & Objective: We aimed to elucidate whether a balanced salt solution decreases the occurrence of contrast-induced acute kidney injury (CI-AKI) after contrast-enhanced computed tomography (CE-CT) as compared to 0.9% saline solution. Study Design: A randomized clinical trial. Setting & Participants: The study was performed in 14 tertiary hospitals in South Korea. Patients with estimated glomerular filtration rates (eGFRs) < 45 or <60 mL/min/1.73 m2 and additional risk factors (age ≥ 60 years or diabetes) who were undergoing scheduled CE-CT were included from December 2016 to December 2018. Intervention: An open-label intervention was performed. The study group received a balanced salt solution and the control group received 0.9% saline solution as prophylactic fluids for CE-CT. Outcomes: The primary outcome was CI-AKI, defined by creatinine level elevation ≥ 0.5 mg/dL or 25% from baseline within 48 to 72 hours after CE-CT. Secondary outcomes included AKI defined based on the KDIGO (Kidney Disease: Improving Global Outcomes) guideline, eGFR changes, death, or requiring dialysis within 6 months after CE-CT. Results: 493 patients received the study fluids. The control and study groups included 251 and 242 patients, respectively. The occurrence of CI-AKI in the study (10 [4.2%]) and control (17 [6.8%]) groups was not significantly different (P = 0.27). No significant difference was present for the secondary outcomes; AKI by the KDIGO definition (study: 19 [7.9%], control: 27 [10.8%]; P = 0.33), death/dialysis (study: 11 [4.7%], control: 9 [3.7%]; P = 0.74), and eGFR changes (study: 0.1 ± 0.2 mg/dL, control: 0.3 ± 2.8 mg/dL; P = 0.69). Limitations: This study failed to meet target enrollment. Conclusions: The risk for CI-AKI was similar after administration of a balanced salt solution and after use of 0.9% saline solution during CE-CT in higher-risk patients. Funding: This study was funded by CJ Healthcare (CS2015_0046). Trial Registration: Registered at ClinicalTrials.gov with study number NCT02799368. © 2020 The Authors | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier Inc. | - |
dc.relation.isPartOf | KIDNEY MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Efficacy and Safety of a Balanced Salt Solution Versus a 0.9% Saline Infusion for the Prevention of Contrast-Induced Acute Kidney Injury After Contrast-Enhanced Computed Tomography | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sehoon Park | - |
dc.contributor.googleauthor | Dong Ki Kim | - |
dc.contributor.googleauthor | Hee-Yeon Jung | - |
dc.contributor.googleauthor | Chan-Duck Kim | - |
dc.contributor.googleauthor | Jang-Hee Cho | - |
dc.contributor.googleauthor | Ran-Hui Cha | - |
dc.contributor.googleauthor | Jong Cheol Jeong | - |
dc.contributor.googleauthor | Sejoong Kim | - |
dc.contributor.googleauthor | Hyung-Jong Kim | - |
dc.contributor.googleauthor | Tae Hyun Ban | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.contributor.googleauthor | Jung Pyo Lee | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Dong-Ryeol Ryu | - |
dc.contributor.googleauthor | Sung Jin Moon | - |
dc.contributor.googleauthor | Jung Eun Lee | - |
dc.contributor.googleauthor | Wooseong Huh | - |
dc.contributor.googleauthor | Ea Wha Kang | - |
dc.contributor.googleauthor | Tae Ik Chang | - |
dc.contributor.googleauthor | Kwon Wook Joo | - |
dc.identifier.doi | 10.1016/j.xkme.2019.12.003 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A04304 | - |
dc.relation.journalcode | J04273 | - |
dc.identifier.eissn | 2590-0595 | - |
dc.identifier.pmid | 32734238 | - |
dc.subject.keyword | acute kidney injury | - |
dc.subject.keyword | acute renal failure | - |
dc.subject.keyword | balanced salt solution | - |
dc.subject.keyword | computed tomography | - |
dc.subject.keyword | Contrast-induced acute kidney injury | - |
dc.subject.keyword | fluid | - |
dc.subject.keyword | saline | - |
dc.contributor.alternativeName | Park, Jung Tak | - |
dc.contributor.affiliatedAuthor | 박정탁 | - |
dc.contributor.affiliatedAuthor | 유태현 | - |
dc.contributor.affiliatedAuthor | 한승혁 | - |
dc.citation.volume | 2 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 189 | - |
dc.citation.endPage | 195 | - |
dc.identifier.bibliographicCitation | KIDNEY MEDICINE, Vol.2(2) : 189-195, 2020-03 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.