10 33

Cited 0 times in

Efficacy and Safety of a Balanced Salt Solution Versus a 0.9% Saline Infusion for the Prevention of Contrast-Induced Acute Kidney Injury After Contrast-Enhanced Computed Tomography

DC Field Value Language
dc.contributor.author박정탁-
dc.contributor.author유태현-
dc.contributor.author한승혁-
dc.date.accessioned2022-09-06T06:07:13Z-
dc.date.available2022-09-06T06:07:13Z-
dc.date.issued2020-03-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/190189-
dc.description.abstractRationale & Objective: We aimed to elucidate whether a balanced salt solution decreases the occurrence of contrast-induced acute kidney injury (CI-AKI) after contrast-enhanced computed tomography (CE-CT) as compared to 0.9% saline solution. Study Design: A randomized clinical trial. Setting & Participants: The study was performed in 14 tertiary hospitals in South Korea. Patients with estimated glomerular filtration rates (eGFRs) < 45 or <60 mL/min/1.73 m2 and additional risk factors (age ≥ 60 years or diabetes) who were undergoing scheduled CE-CT were included from December 2016 to December 2018. Intervention: An open-label intervention was performed. The study group received a balanced salt solution and the control group received 0.9% saline solution as prophylactic fluids for CE-CT. Outcomes: The primary outcome was CI-AKI, defined by creatinine level elevation ≥ 0.5 mg/dL or 25% from baseline within 48 to 72 hours after CE-CT. Secondary outcomes included AKI defined based on the KDIGO (Kidney Disease: Improving Global Outcomes) guideline, eGFR changes, death, or requiring dialysis within 6 months after CE-CT. Results: 493 patients received the study fluids. The control and study groups included 251 and 242 patients, respectively. The occurrence of CI-AKI in the study (10 [4.2%]) and control (17 [6.8%]) groups was not significantly different (P = 0.27). No significant difference was present for the secondary outcomes; AKI by the KDIGO definition (study: 19 [7.9%], control: 27 [10.8%]; P = 0.33), death/dialysis (study: 11 [4.7%], control: 9 [3.7%]; P = 0.74), and eGFR changes (study: 0.1 ± 0.2 mg/dL, control: 0.3 ± 2.8 mg/dL; P = 0.69). Limitations: This study failed to meet target enrollment. Conclusions: The risk for CI-AKI was similar after administration of a balanced salt solution and after use of 0.9% saline solution during CE-CT in higher-risk patients. Funding: This study was funded by CJ Healthcare (CS2015_0046). Trial Registration: Registered at ClinicalTrials.gov with study number NCT02799368. © 2020 The Authors-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherElsevier Inc.-
dc.relation.isPartOfKIDNEY MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEfficacy and Safety of a Balanced Salt Solution Versus a 0.9% Saline Infusion for the Prevention of Contrast-Induced Acute Kidney Injury After Contrast-Enhanced Computed Tomography-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSehoon Park-
dc.contributor.googleauthorDong Ki Kim-
dc.contributor.googleauthorHee-Yeon Jung-
dc.contributor.googleauthorChan-Duck Kim-
dc.contributor.googleauthorJang-Hee Cho-
dc.contributor.googleauthorRan-Hui Cha-
dc.contributor.googleauthorJong Cheol Jeong-
dc.contributor.googleauthorSejoong Kim-
dc.contributor.googleauthorHyung-Jong Kim-
dc.contributor.googleauthorTae Hyun Ban-
dc.contributor.googleauthorByung Ha Chung-
dc.contributor.googleauthorJung Pyo Lee-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorDong-Ryeol Ryu-
dc.contributor.googleauthorSung Jin Moon-
dc.contributor.googleauthorJung Eun Lee-
dc.contributor.googleauthorWooseong Huh-
dc.contributor.googleauthorEa Wha Kang-
dc.contributor.googleauthorTae Ik Chang-
dc.contributor.googleauthorKwon Wook Joo-
dc.identifier.doi10.1016/j.xkme.2019.12.003-
dc.contributor.localIdA01654-
dc.contributor.localIdA02526-
dc.contributor.localIdA04304-
dc.relation.journalcodeJ04273-
dc.identifier.eissn2590-0595-
dc.identifier.pmid32734238-
dc.subject.keywordacute kidney injury-
dc.subject.keywordacute renal failure-
dc.subject.keywordbalanced salt solution-
dc.subject.keywordcomputed tomography-
dc.subject.keywordContrast-induced acute kidney injury-
dc.subject.keywordfluid-
dc.subject.keywordsaline-
dc.contributor.alternativeNamePark, Jung Tak-
dc.contributor.affiliatedAuthor박정탁-
dc.contributor.affiliatedAuthor유태현-
dc.contributor.affiliatedAuthor한승혁-
dc.citation.volume2-
dc.citation.number2-
dc.citation.startPage189-
dc.citation.endPage195-
dc.identifier.bibliographicCitationKIDNEY MEDICINE, Vol.2(2) : 189-195, 2020-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.