Cited 33 times in
Treatment pattern and overall survival in esophageal cancer during a 13-year period: A nationwide cohort study of 6,354 Korean patients
DC Field | Value | Language |
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dc.contributor.author | 박준철 | - |
dc.date.accessioned | 2022-09-06T06:04:25Z | - |
dc.date.available | 2022-09-06T06:04:25Z | - |
dc.date.issued | 2020-04 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190144 | - |
dc.description.abstract | Using data from the real world to solve clinical questions that cannot be answered using data from clinical trials is attracting more attention. Clinical outcomes for patients with esophageal cancer in a real-world setting might be different from data in randomized controlled trials. This study aimed to provide real world data on treatment and prognosis in Korean patients with esophageal cancer. This retrospective cancer cohort included newly diagnosed cases of esophageal cancer at 19 tertiary hospitals between January 1, 2005 and December 31, 2017. Cancer staging was defined according to the 7th edition of the American Joint Committee on Cancer criteria. We identified 6,354 patients with newly diagnosed esophageal cancer (mean age: 64.9 +/- 9.0 years, 96.9% squamous cell carcinoma). The proportion of early esophageal cancer increased from 24.7% in 2005 to 37.2% in 2015 (p<0.001). Among all cases, surgery alone was 31.3%, followed by definitive concurrent chemoradiotherapy (CCRT) (27.0%), neoadjuvant therapy (12.4%), adjuvant therapy (11.1%), and endoscopic resection (5.8%). The 5-year overall survival rate was 45.7 +/- 0.7%. Endoscopic resection provided similar median survival relative to surgery for stage Ia cases. Among stage II-III cases, definitive CCRT was associated with poorer survival than neoadjuvant or adjuvant therapy, although there was no survival difference between neoadjuvant and adjuvant therapy. Early esophageal cancer is gradually becoming more common and endoscopic resection provided similar long-term survival relative to surgery. Surgery with combined therapy provided better survival in locally advanced esophageal cancer, relative to definitive CCRT. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Chemoradiotherapy / methods | - |
dc.subject.MESH | Combined Modality Therapy / methods | - |
dc.subject.MESH | Esophageal Neoplasms / mortality* | - |
dc.subject.MESH | Esophageal Neoplasms / pathology | - |
dc.subject.MESH | Esophageal Neoplasms / therapy* | - |
dc.subject.MESH | Esophageal Squamous Cell Carcinoma / mortality | - |
dc.subject.MESH | Esophageal Squamous Cell Carcinoma / pathology | - |
dc.subject.MESH | Esophageal Squamous Cell Carcinoma / therapy | - |
dc.subject.MESH | Esophagectomy / methods | - |
dc.subject.MESH | Esophagus / pathology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoadjuvant Therapy / methods | - |
dc.subject.MESH | Neoplasm Staging / methods | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Survival Rate | - |
dc.title | Treatment pattern and overall survival in esophageal cancer during a 13-year period: A nationwide cohort study of 6,354 Korean patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hye-Kyung Jung | - |
dc.contributor.googleauthor | Chung Hyun Tae | - |
dc.contributor.googleauthor | Hye-Ah Lee | - |
dc.contributor.googleauthor | Hyuk Lee | - |
dc.contributor.googleauthor | Kee Don Choi | - |
dc.contributor.googleauthor | Jun Chul Park | - |
dc.contributor.googleauthor | Joong Goo Kwon | - |
dc.contributor.googleauthor | Yoon Jin Choi | - |
dc.contributor.googleauthor | Su Jin Hong | - |
dc.contributor.googleauthor | Jaekyu Sung | - |
dc.contributor.googleauthor | Woo Chul Chung | - |
dc.contributor.googleauthor | Ki Bae Kim | - |
dc.contributor.googleauthor | Seung Young Kim | - |
dc.contributor.googleauthor | Kyung Ho Song | - |
dc.contributor.googleauthor | Kyung Sik Park | - |
dc.contributor.googleauthor | Seong Woo Jeon | - |
dc.contributor.googleauthor | Byung-Wook Kim | - |
dc.contributor.googleauthor | Han Seung Ryu | - |
dc.contributor.googleauthor | Ok-Jae Lee | - |
dc.contributor.googleauthor | Gwang Ho Baik | - |
dc.contributor.googleauthor | Yong Sung Kim | - |
dc.contributor.googleauthor | Hwoon-Yong Jung | - |
dc.identifier.doi | 10.1371/journal.pone.0231456 | - |
dc.contributor.localId | A01676 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 32275699 | - |
dc.contributor.alternativeName | Park, Jun Chul | - |
dc.contributor.affiliatedAuthor | 박준철 | - |
dc.citation.volume | 15 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | e0231456 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.15(4) : e0231456, 2020-04 | - |
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