Cited 9 times in
HLA-DRB1*15: 02 Is Associated With Iodinated Contrast Media-Related Anaphylaxis
DC Field | Value | Language |
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dc.contributor.author | 박경희 | - |
dc.date.accessioned | 2022-09-02T01:16:36Z | - |
dc.date.available | 2022-09-02T01:16:36Z | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 0020-9996 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190115 | - |
dc.description.abstract | Background The incidence of severe reaction induced by iodinated contrast media (ICM) has increased over the years with an increasing use of imaging modalities. Although ICM anaphylaxis is rare, it can be life-threatening, but currently, there is no biomarker that can identify individuals at risk of ICM anaphylaxis. Objective The aim of this study is to investigate the genetic susceptibility of ICM anaphylaxis. Methods Patients who had ICM anaphylaxis were enrolled in the study, and their blood samples were collected for genotyping of human leukocyte antigen (HLA)-A, -B, -C, and -DR. The results were compared with those of healthy Korean general population. MRGPRX2 gene in ICM anaphylaxis group was also sequenced and compared with the Korean standard database of genetic polymorphism. Results The frequencies of 3 HLA alleles (B*52:01, C*12:02, and DRB1*15:02) were significantly higher in 47 patients with ICM anaphylaxis. In particular, HLA-DRB1*15:02 was 5 times more frequent in the ICM anaphylaxis group than the Korean general population (34.0% vs 6.6%; odds ratio, 7.306; 95% confidence interval, 3.622-14.740), and this difference was most pronounced in subjects with iohexol-induced anaphylaxis (odds ratio, 16.516; 95% CI, 5.241-52.047; P < 0.0001). Eight single nucleotide polymorphisms were identified in MRGPRX2 gene, but their frequencies were not different in those with ICM anaphylaxis compared with the general Korean population. Conclusions HLA-DRB1*15:02 is associated with ICM anaphylaxis in the Korean population. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | INVESTIGATIVE RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Anaphylaxis / chemically induced* | - |
dc.subject.MESH | Anaphylaxis / genetics | - |
dc.subject.MESH | Anaphylaxis / metabolism | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Contrast Media / adverse effects | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | HLA-DRB1 Chains / genetics* | - |
dc.subject.MESH | HLA-DRB1 Chains / metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Iohexol / adverse effects* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Receptors, G-Protein-Coupled / genetics | - |
dc.subject.MESH | Receptors, Neuropeptide / genetics | - |
dc.title | HLA-DRB1*15: 02 Is Associated With Iodinated Contrast Media-Related Anaphylaxis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Soo Jie Chung | - |
dc.contributor.googleauthor | Dong Yoon Kang | - |
dc.contributor.googleauthor | Whal Lee | - |
dc.contributor.googleauthor | Seung Bok Lee | - |
dc.contributor.googleauthor | Sujeong Kim | - |
dc.contributor.googleauthor | Seung-Eun Lee | - |
dc.contributor.googleauthor | Da Woon Sim | - |
dc.contributor.googleauthor | Min-Gyu Kang | - |
dc.contributor.googleauthor | Kyung Hee Park | - |
dc.contributor.googleauthor | Jae-Woo Jung | - |
dc.contributor.googleauthor | James Yun | - |
dc.contributor.googleauthor | Hye-Ryun Kang | - |
dc.identifier.doi | 10.1097/RLI.0000000000000644 | - |
dc.contributor.localId | A01427 | - |
dc.relation.journalcode | J01188 | - |
dc.identifier.eissn | 1536-0210 | - |
dc.identifier.pmid | 31985601 | - |
dc.identifier.url | https://journals.lww.com/investigativeradiology/Fulltext/2020/05000/HLA_DRB1_15_02_Is_Associated_With_Iodinated.7.aspx | - |
dc.subject.keyword | contrast media | - |
dc.subject.keyword | anaphylaxis | - |
dc.subject.keyword | drug hypersensitivity | - |
dc.subject.keyword | HLA allele | - |
dc.subject.keyword | genetic polymorphism | - |
dc.contributor.alternativeName | Park, Kyung Hee | - |
dc.contributor.affiliatedAuthor | 박경희 | - |
dc.citation.volume | 55 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 304 | - |
dc.citation.endPage | 309 | - |
dc.identifier.bibliographicCitation | INVESTIGATIVE RADIOLOGY, Vol.55(5) : 304-309, 2020-05 | - |
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