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Surgical Outcomes of Hepatocellular Carcinoma With Bile Duct Tumor Thrombus: A Korea-Japan Multicenter Study

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dc.contributor.author한대훈-
dc.date.accessioned2022-09-02T01:15:47Z-
dc.date.available2022-09-02T01:15:47Z-
dc.date.issued2020-05-
dc.identifier.issn0003-4932-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/190099-
dc.description.abstractObjective: To identify optimal surgical methods and the risk factors for long-term survival in patients with hepatocellular carcinoma accompanied by macroscopic bile duct tumor thrombus (BDTT). Summary Background Data: Prognoses of patients with hepatocellular carcinoma accompanied by BDTT have been known to be poor. There have been significant controversies regarding optimal surgical approaches and risk factors because of the low incidence and small number of cases in previous reports. Methods: Records of 257 patients from 32 centers in Korea and Japan (1992-2014) were analyzed for overall survival and recurrence rate using the Cox proportional hazard model. Results: Curative surgery was performed in 244 (94.9%) patients with an operative mortality of 5.1%. Overall survival and recurrence rate at 5 years was 43.6% and 74.2%, respectively. TNM Stage (P< 0.001) and the presence of fibrosis/cirrhosis (P= 0.002) were independent predictors of long-term survival in the Cox proportional hazards regression model. Both performing liver resection equal to or greater than hemihepatectomy and combined bile duct resection significantly increased overall survival [hazard ratio, HR = 0.61 (0.38-0.99);P= 0.044 and HR = 0.51 (0.31-0.84);P= 0.008, respectively] and decreased recurrence rate [HR = 0.59 (0.38-0.91);P= 0.018 and HR = 0.61 (0.42-0.89);P= 0.009, respectively]. Conclusions: Clinical outcomes were mostly influenced by tumor stage and underlying liver function, and the impact of BDTT to survival seemed less prominent than vascular invasion. Therefore, an aggressive surgical approach, including major liver resection combined with bile duct resection, to increase the chance of R0 resection is strongly recommended.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfANNALS OF SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHBile Duct Neoplasms / mortality-
dc.subject.MESHBile Duct Neoplasms / pathology*-
dc.subject.MESHCarcinoma, Hepatocellular / mortality-
dc.subject.MESHCarcinoma, Hepatocellular / surgery*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHJapan-
dc.subject.MESHLiver Neoplasms / mortality-
dc.subject.MESHLiver Neoplasms / surgery*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHRecurrence-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSurvival Rate-
dc.subject.MESHThrombosis / mortality-
dc.subject.MESHThrombosis / pathology*-
dc.titleSurgical Outcomes of Hepatocellular Carcinoma With Bile Duct Tumor Thrombus: A Korea-Japan Multicenter Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorDong-Sik Kim-
dc.contributor.googleauthorBong-Wan Kim-
dc.contributor.googleauthorEtsuro Hatano-
dc.contributor.googleauthorShin Hwang-
dc.contributor.googleauthorKiyoshi Hasegawa-
dc.contributor.googleauthorAtsushi Kudo-
dc.contributor.googleauthorShunichi Ariizumi-
dc.contributor.googleauthorMasaki Kaibori-
dc.contributor.googleauthorTakumi Fukumoto-
dc.contributor.googleauthorHideo Baba-
dc.contributor.googleauthorSeong Hoon Kim-
dc.contributor.googleauthorShoji Kubo-
dc.contributor.googleauthorJong Man Kim-
dc.contributor.googleauthorKeun Soo Ahn-
dc.contributor.googleauthorSae Byeol Choi-
dc.contributor.googleauthorChi-Young Jeong-
dc.contributor.googleauthorYasuo Shima-
dc.contributor.googleauthorHiroaki Nagano-
dc.contributor.googleauthorOsamu Yamasaki-
dc.contributor.googleauthorHee Chul Yu-
dc.contributor.googleauthorDai Hoon Han-
dc.contributor.googleauthorHyung-Il Seo-
dc.contributor.googleauthorIl-Young Park-
dc.contributor.googleauthorKyung-Sook Yang-
dc.contributor.googleauthorMasakazu Yamamoto-
dc.contributor.googleauthorHee-Jung Wang-
dc.identifier.doi10.1097/SLA.0000000000003014-
dc.contributor.localIdA04273-
dc.relation.journalcodeJ00178-
dc.identifier.eissn1528-1140 (-
dc.identifier.pmid30216223-
dc.identifier.urlhttps://journals.lww.com/annalsofsurgery/Fulltext/2020/05000/Surgical_Outcomes_of_Hepatocellular_Carcinoma_With.20.aspx-
dc.subject.keywordbile duct resection-
dc.subject.keywordjaundice-
dc.subject.keywordliver resection-
dc.subject.keywordprognosis-
dc.subject.keywordsurvival-
dc.subject.keywordthrombectomy-
dc.contributor.alternativeNameHan, Dai Hoon-
dc.contributor.affiliatedAuthor한대훈-
dc.citation.volume271-
dc.citation.number5-
dc.citation.startPage913-
dc.citation.endPage921-
dc.identifier.bibliographicCitationANNALS OF SURGERY, Vol.271(5) : 913-921, 2020-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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