Cited 11 times in
Improvement of medication adherence with simplified once-daily immunosuppressive regimen in stable kidney transplant recipients: A prospective cohort study
DC Field | Value | Language |
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dc.contributor.author | 김유선 | - |
dc.contributor.author | 허규하 | - |
dc.date.accessioned | 2022-09-02T01:14:58Z | - |
dc.date.available | 2022-09-02T01:14:58Z | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 1015-9584 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190086 | - |
dc.description.abstract | Background: Many immunosuppressive drugs are prescribed as twice-daily dosing. A simplified once-daily dosing of immunosuppressive drug regimen may improve medication adherence. We investigated medication adherence of simplified once-daily immunosuppressive regimen consisting of extended-release tacrolimus, sirolimus, and corticosteroids along with the efficacy and safety of this regimen. Methods: This study was a prospective, multicenter, controlled and cohort trial. Stable kidney transplant recipients who had received transplantation at least 3 months before the study enrollment were eligible for the study. Participants were required to fill-out the self-reported immunosuppressant therapy barrier scale (ITBS) questionnaire before and after the conversion. Other clinical laboratory parameters and adverse events were evaluated until 6 months post-conversion. Results: A total of 160 kidney recipients comprised the intention-to-treat population. The mean total ITBS score was 19.5 +/- 14.0 at pre-conversion and 6 months after converting, the mean total ITBS score was 16.6 +/- 13.6 (p < 0.001). Particularly, the ITBS scores of 4 questions related to the frequency of medication dosing were significantly different between pre-conversion and post-conversion. Only 1 patient (0.62%) was diagnosed as biopsy-confirmed acute rejection in the study period. There was no significant change in the mean estimated glomerular filtration rate after the conversion. Overall 95 patients (59.4%) had an adverse event and 28 patients (17.5%) had a serious adverse event. No graft loss and 1 death were reported. Conclusion: Medication adherence after the conversion to the once-daily immunosuppressive regimen was significantly improved with no additional risks of efficacy failure or adverse events. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Excerpta Media Asia | - |
dc.relation.isPartOf | ASIAN JOURNAL OF SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adrenal Cortex Hormones / administration & dosage* | - |
dc.subject.MESH | Adrenal Cortex Hormones / adverse effects | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Drug Administration Schedule* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunosuppressive Agents / administration & dosage* | - |
dc.subject.MESH | Immunosuppressive Agents / adverse effects | - |
dc.subject.MESH | Kidney Transplantation* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Medication Adherence* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Patient Outcome Assessment | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Sirolimus / administration & dosage* | - |
dc.subject.MESH | Sirolimus / adverse effects | - |
dc.subject.MESH | Surveys and Questionnaires | - |
dc.subject.MESH | Tacrolimus / administration & dosage* | - |
dc.subject.MESH | Tacrolimus / adverse effects | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Improvement of medication adherence with simplified once-daily immunosuppressive regimen in stable kidney transplant recipients: A prospective cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Chang-Kwon Oh | - |
dc.contributor.googleauthor | Jun Bae Bang | - |
dc.contributor.googleauthor | Sung-Joo Kim | - |
dc.contributor.googleauthor | Kyu Ha Huh | - |
dc.contributor.googleauthor | Soo Jin Kim | - |
dc.contributor.googleauthor | Jin Seok Jeon | - |
dc.contributor.googleauthor | Sang Youb Han | - |
dc.contributor.googleauthor | Hong Rae Cho | - |
dc.contributor.googleauthor | Young Joo Kwon | - |
dc.contributor.googleauthor | Su Hyung Lee | - |
dc.contributor.googleauthor | Yu Seun Kim | - |
dc.identifier.doi | 10.1016/j.asjsur.2019.07.011 | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A04344 | - |
dc.relation.journalcode | J03114 | - |
dc.identifier.eissn | 0219-3108 | - |
dc.identifier.pmid | 31353239 | - |
dc.subject.keyword | Medication adherence | - |
dc.subject.keyword | Kidney transplantation | - |
dc.subject.keyword | Immunosuppression | - |
dc.subject.keyword | Tacrolimus | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | 김유선 | - |
dc.contributor.affiliatedAuthor | 허규하 | - |
dc.citation.volume | 43 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 660 | - |
dc.citation.endPage | 667 | - |
dc.identifier.bibliographicCitation | ASIAN JOURNAL OF SURGERY, Vol.43(6) : 660-667, 2020-06 | - |
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