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Engineering Microphysiological Immune System Responses on Chips

Authors
 Chris P Miller  ;  Woojung Shin  ;  Eun Hyun Ahn  ;  Hyun Jung Kim  ;  Deok-Ho Kim 
Citation
 TRENDS IN BIOTECHNOLOGY, Vol.38(8) : 857-872, 2020-08 
Journal Title
TRENDS IN BIOTECHNOLOGY
ISSN
 0167-7799 
Issue Date
2020-08
MeSH
Humans ; Immune System ; Immunity / genetics* ; Immunity / immunology ; Lab-On-A-Chip Devices* ; Microfluidics ; Neoplasms / genetics ; Neoplasms / immunology* ; Tumor Microenvironment / genetics ; Tumor Microenvironment / immunology*
Keywords
engineering immune system responses ; immune system-on-a-chip ; intestinal inflammation ; microphysiological systems ; systems immunology ; tumor immune microenvironment
Abstract
Tissues- and organs-on-chips are microphysiological systems (MPSs) that model the architectural and functional complexity of human tissues and organs that is lacking in conventional cell monolayer cultures. While substantial progress has been made in a variety of tissues and organs, chips recapitulating immune responses have not advanced as rapidly. This review discusses recent progress in MPSs for the investigation of immune responses. To illustrate recent developments, we focus on two cases in point: immunocompetent tumor microenvironment-on-a-chip devices that incorporate stromal and immune cell components and pathomimetic modeling of human mucosal immunity and inflammatory crosstalk. More broadly, we discuss the development of systems immunology-on-a-chip devices that integrate microfluidic engineering approaches with high-throughput omics measurements and emerging immunological applications of MPSs.
Files in This Item:
T9992020242.pdf Download
DOI
10.1016/j.tibtech.2020.01.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190020
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