Cited 6 times in
Serum FAM19A5 in neuromyelitis optica spectrum disorders: Can it be a new biomarker representing clinical status?
DC Field | Value | Language |
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dc.contributor.author | 신하영 | - |
dc.date.accessioned | 2022-09-02T01:06:05Z | - |
dc.date.available | 2022-09-02T01:06:05Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 1352-4585 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189936 | - |
dc.description.abstract | Background: Neuromyelitis optica spectrum disorder (NMOSD) targets astrocytes and elevates the levels of astrocyte-injury markers during attacks. FAM19A5, involved in reactive gliosis, is secreted by reactive astrocytes following central nervous system (CNS) damage. Objective: To investigate the significance of serum FAM19A5 in patients with NMOSD. Methods: We collected clinical data and sera of 199 patients from 11 hospitals over 21 months. FAM19A5 levels were compared among three groups: NMOSD with positive anti-aquaporin-4 antibody (NMOSD-AQP4), other CNS demyelinating disease, and healthy controls. Results: The median serum FAM19A5 level was higher in the NMOSD-AQP4 (4.90 ng/mL (3.95, 5.79)) than in the other CNS demyelinating (2.35 ng/mL (1.83, 4.07), p < 0.001) or healthy control (1.02 ng/mL (0.92, 1.14), p < 0.001) groups. There were significant differences in the median serum FAM19A5 levels between the attack and remission periods (5.89 ng/mL (5.18, 6.98); 4.40 ng/mL (2.72, 5.13), p < 0.001) in the NMOSD-AQP4 group. Sampling during an attack (p < 0.001) and number of past attacks (p = 0.010) were independently associated with increased serum FAM19A5. Conclusion: Serum FAM19A5 was higher in patients with NMOSD-AQP4 and correlated with clinical characteristics. Thus, serum FAM19A5 may be a novel clinical biomarker for NMOSD-AQP4. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | SAGE Publications | - |
dc.relation.isPartOf | MULTIPLE SCLEROSIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aquaporin 4 | - |
dc.subject.MESH | Autoantibodies | - |
dc.subject.MESH | Biomarkers | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Myelin-Oligodendrocyte Glycoprotein | - |
dc.subject.MESH | Neuromyelitis Optica* / diagnosis | - |
dc.title | Serum FAM19A5 in neuromyelitis optica spectrum disorders: Can it be a new biomarker representing clinical status? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Hye Lim Lee | - |
dc.contributor.googleauthor | Hung Youl Seok | - |
dc.contributor.googleauthor | Han-Wook Ryu | - |
dc.contributor.googleauthor | Eun Bee Cho | - |
dc.contributor.googleauthor | Bong Chul Kim | - |
dc.contributor.googleauthor | Byoung Joon Kim | - |
dc.contributor.googleauthor | Ju-Hong Min | - |
dc.contributor.googleauthor | Jin Myoung Seok | - |
dc.contributor.googleauthor | Ha Young Shin | - |
dc.contributor.googleauthor | Sa-Yoon Kang | - |
dc.contributor.googleauthor | Oh-Hyun Kwon | - |
dc.contributor.googleauthor | Sang-Soo Lee | - |
dc.contributor.googleauthor | Jeeyoung Oh | - |
dc.contributor.googleauthor | Eun-Hee Sohn | - |
dc.contributor.googleauthor | So-Young Huh | - |
dc.contributor.googleauthor | Joong-Yang Cho | - |
dc.contributor.googleauthor | Jae Young Seong | - |
dc.contributor.googleauthor | Byung-Jo Kim | - |
dc.identifier.doi | 10.1177/1352458519885489 | - |
dc.contributor.localId | A02170 | - |
dc.relation.journalcode | J04083 | - |
dc.identifier.eissn | 1477-0970 | - |
dc.identifier.pmid | 31680620 | - |
dc.identifier.url | https://journals.sagepub.com/doi/10.1177/1352458519885489 | - |
dc.subject.keyword | Neuromyelitis optica spectrum disorder | - |
dc.subject.keyword | astrocyte | - |
dc.subject.keyword | reactive gliosis | - |
dc.subject.keyword | CNS demyelinating disease | - |
dc.subject.keyword | MOG associated disease | - |
dc.contributor.alternativeName | Shin, Ha Young | - |
dc.contributor.affiliatedAuthor | 신하영 | - |
dc.citation.volume | 26 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 1700 | - |
dc.citation.endPage | 1707 | - |
dc.identifier.bibliographicCitation | MULTIPLE SCLEROSIS, Vol.26(13) : 1700-1707, 2020-11 | - |
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