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Risk Factors of Microscopically Tumor-Free Surgical Margins for Recurrence and Survival of Oral Squamous Cell Carcinoma Patients
DC Field | Value | Language |
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dc.contributor.author | 김기열 | - |
dc.contributor.author | 김동욱 | - |
dc.contributor.author | 김현실 | - |
dc.contributor.author | 김형준 | - |
dc.contributor.author | 남웅 | - |
dc.contributor.author | 장향란 | - |
dc.contributor.author | 조은애산드라 | - |
dc.contributor.author | 차인호 | - |
dc.date.accessioned | 2022-08-23T00:42:58Z | - |
dc.date.available | 2022-08-23T00:42:58Z | - |
dc.date.issued | 2022-07 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189582 | - |
dc.description.abstract | Objectives: The concept of adequate surgical margins remains controversial in oral squamous cell carcinoma (OSCC) surgery. This study aimed to identify surgical margin-related indicators that might impact recurrence and survival of OSCC patients. Materials and methods: Histopathological examination was performed using hematoxylin-eosin-stained surgical margin tissue sections in 235 OSCC patients. Axin2 and Snail expression at the surgical margin was detected by immunohistochemistry. The impact of the Axin2-Snail cascade on tumorigenesis of the immortalized human oral keratinocyte (IHOK) line was investigated in vivo. Results: The width and dysplasia of surgical margins were not significantly associated with the outcome of OSCC patients. In a multivariate analysis using variable clinicopathologic factors and with Axin2 and Snail expression as cofactors, higher age (hazard ratio [HR]:1.050; P=0.047), Axin2 (HR:6.883; P=0.014), and Snail abundance (HR:5.663; P=0.009) had independent impacts on worsened overall survival. Similarly, lesion site in retromolar trigone (HR:4.077; P=0.010), upper (HR:4.332; P=0.005) and lower gingiva (HR:3.545; P=0.012), presence of extranodal extension (HR:9.967; P<0.001), perineural invasion (HR:3.627; P=0.024), and Snail abundance (HR:3.587; P<0.001) had independent impacts on worsened recurrence-free survival. Furthermore, Axin2 knockdown induced decreased Snail expression and attenuated tumorigenesis in the IHOK line. Conclusion: Histopathological examination of surgical margins may not be reliable to predict OSCC patient outcome. Molecular analysis may provide a more accurate risk assessment of surgical margins in OSCC. In particular, Axin2 and Snail are potential predictive biomarkers for the risk assessment of surgical margins in OSCC. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Frontiers Research Foundation | - |
dc.relation.isPartOf | FRONTIERS IN ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Risk Factors of Microscopically Tumor-Free Surgical Margins for Recurrence and Survival of Oral Squamous Cell Carcinoma Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Others | - |
dc.contributor.googleauthor | Meiling Pei | - |
dc.contributor.googleauthor | Dawool Han | - |
dc.contributor.googleauthor | Ki-Yeol Kim | - |
dc.contributor.googleauthor | Dong Wook Kim | - |
dc.contributor.googleauthor | Woong Nam | - |
dc.contributor.googleauthor | Hyung Jun Kim | - |
dc.contributor.googleauthor | Eunae Sandra Cho | - |
dc.contributor.googleauthor | Hyun Sil Kim | - |
dc.contributor.googleauthor | In-Ho Cha | - |
dc.contributor.googleauthor | Xianglan Zhang | - |
dc.identifier.doi | 10.3389/fonc.2022.930988 | - |
dc.contributor.localId | A00337 | - |
dc.contributor.localId | A05613 | - |
dc.contributor.localId | A01121 | - |
dc.contributor.localId | A01156 | - |
dc.contributor.localId | A01260 | - |
dc.contributor.localId | A03489 | - |
dc.contributor.localId | A04799 | - |
dc.contributor.localId | A04002 | - |
dc.relation.journalcode | J03512 | - |
dc.identifier.eissn | 2234-943X | - |
dc.identifier.pmid | 35875099 | - |
dc.subject.keyword | OSCC | - |
dc.subject.keyword | axin2 | - |
dc.subject.keyword | molecular markers | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | recurrence | - |
dc.subject.keyword | risk assessment | - |
dc.subject.keyword | snail | - |
dc.subject.keyword | surgical margin | - |
dc.contributor.alternativeName | Kim, Ki Yeol | - |
dc.contributor.affiliatedAuthor | 김기열 | - |
dc.contributor.affiliatedAuthor | 김동욱 | - |
dc.contributor.affiliatedAuthor | 김현실 | - |
dc.contributor.affiliatedAuthor | 김형준 | - |
dc.contributor.affiliatedAuthor | 남웅 | - |
dc.contributor.affiliatedAuthor | 장향란 | - |
dc.contributor.affiliatedAuthor | 조은애산드라 | - |
dc.contributor.affiliatedAuthor | 차인호 | - |
dc.citation.volume | 12 | - |
dc.citation.startPage | 930988 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN ONCOLOGY, Vol.12 : 930988, 2022-07 | - |
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