Cited 10 times in
The presence and size of intrahepatic tumors determine the therapeutic efficacy of nivolumab in advanced hepatocellular carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김창곤 | - |
dc.contributor.author | 김한상 | - |
dc.contributor.author | 신상준 | - |
dc.contributor.author | 최혜진 | - |
dc.date.accessioned | 2022-08-23T00:40:51Z | - |
dc.date.available | 2022-08-23T00:40:51Z | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 1758-8340 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189563 | - |
dc.description.abstract | Purpose: Inter-tumoral heterogeneity at the differential lesion level raises the possibility of distinct organ-specific responses to immune checkpoint inhibitors (ICIs). We aimed to comprehensively examine the clinicopathological factors to predict and assess the efficacy of nivolumab, programmed cell death protein 1 (PD-1) blockade at an individual tumor site-specific level in patients with advanced hepatocellular carcinoma (aHCC). Patients and methods: We enrolled 261 aHCC patients treated with nivolumab between 2012 and 2018. Eighty-one clinicopathological factors were comprehensively collected and analyzed. The association between all variables and survival outcomes was evaluated. According to tumor site, the organ-specific responses were assessed based on the Response Evaluation Criteria in Solid Tumors, version 1.1. Results: The liver was the most commonly involved organ (75.1%), followed by the lungs (37.5%) and lymph nodes (LNs, 11.5%). The liver of nonresponders was more frequently the organ of progression, while the lungs of responders were more frequently the organs of response. Among the 455 individual lesions (liver, n = 248; lung, n = 124; LN, n = 35; others including bone or soft tissues, n = 48), intrahepatic tumors showed the least response (10.1%), followed by lung (24.2%) and LN tumors (37.1%), indicating the presence of distinct organ-specific responses to nivolumab. In intrahepatic tumors, the organ-specific response rate decreased as the size increased (13% for ⩽50 mm, 8.1% for 50-100 mm, and 5.5% for >100 mm). In the subgroup analysis according to tumor location, patients with lung only metastasis (⩾30 mm) showed the best progression-free survival (PFS) and overall survival (OS). In contrast, primary HCC (⩾100 mm) without lung metastasis had the worst PFS and OS. Comprehensive analyses also revealed that liver function and systemic inflammatory indices, such as neutrophil-to-lymphocyte ratio (NLR), were significantly associated with PFS and OS. Conclusion: The presence and size of liver tumors, liver function, and NLR are key factors determining the response to nivolumab in aHCC. These clinical factors should be considered when treating patients with advanced HCC with PD-1 blockade. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Sage | - |
dc.relation.isPartOf | THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | The presence and size of intrahepatic tumors determine the therapeutic efficacy of nivolumab in advanced hepatocellular carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Han Sang Kim | - |
dc.contributor.googleauthor | Chang Gon Kim | - |
dc.contributor.googleauthor | Jung Yong Hong | - |
dc.contributor.googleauthor | Il-Hwan Kim | - |
dc.contributor.googleauthor | Beodeul Kang | - |
dc.contributor.googleauthor | Sanghoon Jung | - |
dc.contributor.googleauthor | Chan Kim | - |
dc.contributor.googleauthor | Sang Joon Shin | - |
dc.contributor.googleauthor | Hye Jin Choi | - |
dc.contributor.googleauthor | Jaekyung Cheon | - |
dc.contributor.googleauthor | Hong Jae Chon | - |
dc.contributor.googleauthor | Ho Yeong Lim | - |
dc.identifier.doi | 10.1177/17588359221113266 | - |
dc.contributor.localId | A05991 | - |
dc.contributor.localId | A01098 | - |
dc.contributor.localId | A02105 | - |
dc.contributor.localId | A04219 | - |
dc.relation.journalcode | J02720 | - |
dc.identifier.eissn | 1758-8359 | - |
dc.identifier.pmid | 35860833 | - |
dc.subject.keyword | PD-1 blockade | - |
dc.subject.keyword | clinicopathologic factors | - |
dc.subject.keyword | hepatocellular carcinoma | - |
dc.subject.keyword | lesion-level response | - |
dc.subject.keyword | outcome | - |
dc.contributor.alternativeName | Kim, Chang Gon | - |
dc.contributor.affiliatedAuthor | 김창곤 | - |
dc.contributor.affiliatedAuthor | 김한상 | - |
dc.contributor.affiliatedAuthor | 신상준 | - |
dc.contributor.affiliatedAuthor | 최혜진 | - |
dc.citation.volume | 14 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 13 | - |
dc.identifier.bibliographicCitation | THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, Vol.14 : 1-13, 2022-07 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.