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HLA-I-restricted CD8 + T cell immunity may accelerate tumorigenesis in conjunction with VHL inactivation
DC Field | Value | Language |
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dc.contributor.author | 김상우 | - |
dc.contributor.author | 정인경 | - |
dc.contributor.author | 허석재 | - |
dc.date.accessioned | 2022-08-23T00:39:12Z | - |
dc.date.available | 2022-08-23T00:39:12Z | - |
dc.date.issued | 2022-06 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189547 | - |
dc.description.abstract | CD8+ T cells recognize and kill tumor cells with HLA-I tumor antigens in early tumorigenesis, the efficiency of which differs according to antigen-recognition coverage, as shown in earlier tumor onset in HLA-I homozygosity. However, the universality of these associations remains unknown. Here, we assessed the tumor type and driver mutation specificity in the association between tumor onset age and HLA-I zygosity. Statistical analyses identified an unexpected negative relationship in tumors with VHL biallelic loss, wherein HLA-I heterozygosity was associated with earlier tumor onset, while all others showed either no or a positive association. Testing on an independent dataset reproduced the VHL-dependent acceleration of tumor onset in the HLA-I heterozygous group, confirming the association. Further speculation proposed VEGF-A-mediated T cell exhaustion under VHL inactivation as a potential mechanism. Our findings suggest that CD8+ T cell immunity in early tumor suppression can be conditional to the genetic status of tumors and may even lead to adverse consequences. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.relation.isPartOf | ISCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | HLA-I-restricted CD8 + T cell immunity may accelerate tumorigenesis in conjunction with VHL inactivation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) | - |
dc.contributor.googleauthor | BeumJin Park | - |
dc.contributor.googleauthor | Seok-Jae Heo | - |
dc.contributor.googleauthor | Yong Joon Lee | - |
dc.contributor.googleauthor | Mi-Kyoung Seo | - |
dc.contributor.googleauthor | Jiyun Hong | - |
dc.contributor.googleauthor | Eui-Cheol Shin | - |
dc.contributor.googleauthor | Inkyung Jung | - |
dc.contributor.googleauthor | Sangwoo Kim | - |
dc.identifier.doi | 10.1016/j.isci.2022.104467 | - |
dc.contributor.localId | A00524 | - |
dc.contributor.localId | A03693 | - |
dc.relation.journalcode | J03874 | - |
dc.identifier.eissn | 2589-0042 | - |
dc.identifier.pmid | 35677644 | - |
dc.subject.keyword | Cancer | - |
dc.subject.keyword | Components of the immune system | - |
dc.subject.keyword | Immunology | - |
dc.contributor.alternativeName | Kim, Sang Woo | - |
dc.contributor.affiliatedAuthor | 김상우 | - |
dc.contributor.affiliatedAuthor | 정인경 | - |
dc.citation.volume | 25 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 104467 | - |
dc.identifier.bibliographicCitation | ISCIENCE, Vol.25(6) : 104467, 2022-06 | - |
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