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Comparison of pharmacologic therapies alone versus operative techniques in combination with pharmacologic therapies for postoperative analgesia in patients undergoing laparoscopic cholecystectomy: A randomized controlled trial
DC Field | Value | Language |
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dc.contributor.author | 김도형 | - |
dc.contributor.author | 김현창 | - |
dc.contributor.author | 송영 | - |
dc.contributor.author | 이종석 | - |
dc.contributor.author | 임진홍 | - |
dc.date.accessioned | 2022-08-23T00:34:24Z | - |
dc.date.available | 2022-08-23T00:34:24Z | - |
dc.date.issued | 2022-08 | - |
dc.identifier.issn | 1743-9191 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189504 | - |
dc.description.abstract | Background: Laparoscopic cholecystectomy (LC) causes moderate pain. Various operative analgesic techniques and pharmacologic treatments can reduce postoperative pain. This single-center, single-surgeon randomized controlled study aimed to assess the efficacy of combined operative analgesic techniques and pharmacologic analgesia in decreasing pain in patients undergoing LC. Materials and methods: Fifty-nine patients scheduled for LC were assigned into two groups. In the pharmacologic analgesia (P) group (n = 29), patients were treated with pharmacologic intervention, including preoperative celecoxib (200 mg), intraoperative acetaminophen (1 g), and dexamethasone (8 mg). In the operative analgesic treatments with pharmacologic analgesia (OP) group (n = 30), patients were treated with both operative analgesic techniques and pharmacologic analgesia, including low-pressure pneumoperitoneum, intraperitoneal normal saline irrigation, and aspiration of intraperitoneal carbon dioxide. The area under the curve (AUC) of pain score for postoperative 24 h was assessed at 0, 2, 6, and 24 h post-operation. The analgesic requirements and sleep quality at postoperative day 1 were assessed. Results: The AUC/24 h of pain scores at rest and on cough were lower in the OP group (p < 0.001 and p = 0.001, respectively). The pain scores at rest were lower in the OP group at postoperative 2, 6, and 24 h (p = 0.001, p = 0.001, and p = 0.048, respectively). The pain scores on cough were lower in the OP group at postoperative 2 and 6 h (p = 0.004 and p = 0.008, respectively). Analgesic requirements were comparable. The sleep quality score at postoperative day 1 was higher in the OP group (56 ± 18 vs. 67 ± 15, absolute difference, 10; 95% confidence interval, 2 to 19; p = 0.017). Conclusions: Combined operative analgesic therapies and pharmacologic analgesia compared to pharmacologic analgesia alone decreased pain scores and increased sleep quality in patients undergoing LC. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Comparison of pharmacologic therapies alone versus operative techniques in combination with pharmacologic therapies for postoperative analgesia in patients undergoing laparoscopic cholecystectomy: A randomized controlled trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Hyun-Chang Kim | - |
dc.contributor.googleauthor | Young Song | - |
dc.contributor.googleauthor | Jong Seok Lee | - |
dc.contributor.googleauthor | Myeong Eun Jeong | - |
dc.contributor.googleauthor | Yongmin Lee | - |
dc.contributor.googleauthor | Jin Hong Lim | - |
dc.contributor.googleauthor | Do-Hyeong Kim | - |
dc.identifier.doi | 10.1016/j.ijsu.2022.106763 | - |
dc.contributor.localId | A00390 | - |
dc.contributor.localId | A06091 | - |
dc.contributor.localId | A02036 | - |
dc.contributor.localId | A03141 | - |
dc.contributor.localId | A03411 | - |
dc.relation.journalcode | J01162 | - |
dc.identifier.eissn | 1743-9159 | - |
dc.identifier.pmid | 35803512 | - |
dc.subject.keyword | Analgesia | - |
dc.subject.keyword | Cholecystectomy | - |
dc.subject.keyword | Pharmacotherapy | - |
dc.subject.keyword | Pneumoperitoneum | - |
dc.subject.keyword | Surgery | - |
dc.contributor.alternativeName | Kim, Do Hyeong | - |
dc.contributor.affiliatedAuthor | 김도형 | - |
dc.contributor.affiliatedAuthor | 김현창 | - |
dc.contributor.affiliatedAuthor | 송영 | - |
dc.contributor.affiliatedAuthor | 이종석 | - |
dc.contributor.affiliatedAuthor | 임진홍 | - |
dc.citation.volume | 104 | - |
dc.citation.startPage | 106763 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF SURGERY, Vol.104 : 106763, 2022-08 | - |
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