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PD-L1 expression and overall survival in Asian and western patients with gastric cancer

Authors
 Sun Young Rha  ;  Geoffrey Y Ku  ;  Hyo Song Kim  ;  Hyun Cheol Chung  ;  Fatemeh Ghazanfari Amlashi  ;  Dipen Maheshbhai Maru  ;  Carly A Fein  ;  Laura H Tang  ;  Wei Zhou  ;  Ting Wu  ;  Senaka A Peter  ;  David P Kelsen  ;  Jaffer A Ajani 
Citation
 FUTURE ONCOLOGY, Vol.18(21) : 2623-2634, 2022-07 
Journal Title
FUTURE ONCOLOGY
ISSN
 1479-6694 
Issue Date
2022-07
MeSH
B7-H1 Antigen* / metabolism ; Biomarkers, Tumor / metabolism ; Humans ; Retrospective Studies ; Stomach Neoplasms* / pathology
Keywords
PD-L1 ; expression ; gastric cancer ; overall survival ; prognosis
Abstract
Aim: Data are limited on PD-L1 expression and its association with overall survival (OS) in gastric cancer (GC) patients receiving routine care in different regions. Materials & methods: In a retrospective study, PD-L1 expression was assayed using the 22C3 pharmDx on GC tumor samples collected between 2003 and 2017 at South Korean and US cancer centers. PD-L1 positivity was defined as combined positive score (CPS) ≥1. The relationship between PD-L1 and OS was analyzed. Results: Of 574 GC tumor samples, 67.4% were CPS ≥1 (68.7% in Korean and 65.7% in US patients). PD-L1 expression was not associated with OS (adjusted hazard ratio: 0.94; 95% CI: 0.75-1.17). Conclusion: PD-L1 prevalence and its association with OS was similar between South Korean and US GC patients.
Full Text
https://www.futuremedicine.com/doi/10.2217/fon-2022-0103?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&
DOI
10.2217/fon-2022-0103
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyo Song(김효송) ORCID logo https://orcid.org/0000-0002-0625-9828
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/189453
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