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Effects of Dose Titration on Dipyridamole-Induced Headache: A Randomized, Double-Blind Clinical Trial
DC Field | Value | Language |
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dc.contributor.author | 이경열 | - |
dc.date.accessioned | 2022-08-23T00:27:07Z | - |
dc.date.available | 2022-08-23T00:27:07Z | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 1015-9770 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189437 | - |
dc.description.abstract | Purpose: The aim of this study is to investigate the effect of gradual dipyridamole titration and the incidence of dipyridamole-induced headache in patients with ischemic stroke or transient ischemic attack (TIA). Methods: A randomized, double-blind, double-placebo, parallel group, phase 4 clinical trial (KCT0005457) was conducted between July 1, 2019, and February 25, 2020, at 15 medical centers in South Korea. The study included patients aged >19 years diagnosed with a noncardioembolic ischemic stroke or TIA within the previous 3 weeks. The participants were randomized 1:1:1 to receive Adinox® (aspirin 25 mg/dipyridamole 200 mg) and aspirin (100 mg) once daily for the first 2 weeks followed by Adinox® twice daily for 2 weeks (titration group), Adinox® twice daily for 4 weeks (standard group), and aspirin 100 mg once daily for 4 weeks (control group). The primary endpoint was incidence of headache over 4 weeks. The key secondary endpoint was mean cumulative headache. Results: Ninety-six patients were randomized into the titration (n = 31), standard (n = 32), and control (n = 33) groups. The titration and standard groups (74.1% vs. 74.2%, respectively) showed no difference in the primary endpoint. However, the mean cumulated headache was significantly lower in the titration group than in the standard group (0.31 ± 0.46 vs. 0.58 ± 0.51, p = 0.023). Further, adverse drug reactions were more common in the standard group than in the titration group (28.1% vs. 9.7%, respectively, p = 0.054), although not significantly different. Conclusion: The titration strategy was effective in lowering the incidence of cumulative dipyridamole-induced headache. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Karger | - |
dc.relation.isPartOf | CEREBROVASCULAR DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aspirin / adverse effects | - |
dc.subject.MESH | Dipyridamole / adverse effects | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Headache / chemically induced | - |
dc.subject.MESH | Headache / diagnosis | - |
dc.subject.MESH | Headache / drug therapy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ischemic Attack, Transient* / diagnosis | - |
dc.subject.MESH | Ischemic Attack, Transient* / drug therapy | - |
dc.subject.MESH | Ischemic Stroke* | - |
dc.subject.MESH | Platelet Aggregation Inhibitors | - |
dc.subject.MESH | Stroke* / diagnosis | - |
dc.subject.MESH | Stroke* / drug therapy | - |
dc.title | Effects of Dose Titration on Dipyridamole-Induced Headache: A Randomized, Double-Blind Clinical Trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Min Kyoung Kang | - |
dc.contributor.googleauthor | Jae-Kwan Cha | - |
dc.contributor.googleauthor | Dae-Il Chang | - |
dc.contributor.googleauthor | Hyun Young Kim | - |
dc.contributor.googleauthor | Jong-Won Chung | - |
dc.contributor.googleauthor | Keun-Hwa Jung | - |
dc.contributor.googleauthor | Keun-Sik Hong | - |
dc.contributor.googleauthor | Jun Young Chang | - |
dc.contributor.googleauthor | Joung-Ho Rha | - |
dc.contributor.googleauthor | Jong-Moo Park | - |
dc.contributor.googleauthor | Byung-Kun Kim | - |
dc.contributor.googleauthor | Soo Joo Lee | - |
dc.contributor.googleauthor | Man-Seok Park | - |
dc.contributor.googleauthor | Kyung-Yul Lee | - |
dc.contributor.googleauthor | Dong-Ick Shin | - |
dc.contributor.googleauthor | Byung-Woo Yoon | - |
dc.identifier.doi | 10.1159/000521083 | - |
dc.contributor.localId | A02648 | - |
dc.relation.journalcode | J00506 | - |
dc.identifier.eissn | 1421-9786 | - |
dc.identifier.pmid | 35034023 | - |
dc.identifier.url | https://www.karger.com/Article/FullText/521083 | - |
dc.subject.keyword | Dipyridamole | - |
dc.subject.keyword | Headache | - |
dc.subject.keyword | Stroke | - |
dc.subject.keyword | Titration strategy | - |
dc.contributor.alternativeName | Lee, Kyung Yul | - |
dc.contributor.affiliatedAuthor | 이경열 | - |
dc.citation.volume | 51 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 493 | - |
dc.citation.endPage | 498 | - |
dc.identifier.bibliographicCitation | CEREBROVASCULAR DISEASES, Vol.51(4) : 493-498, 2022-07 | - |
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