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Statin Therapy in HIGH-Risk Individuals with NORMal Coronary Arteries: The HIGH-NORM Study

DC Field Value Language
dc.contributor.author강석민-
dc.contributor.author박성하-
dc.contributor.author오재원-
dc.contributor.author이상학-
dc.contributor.author이찬주-
dc.contributor.author전경현-
dc.date.accessioned2022-08-23T00:24:24Z-
dc.date.available2022-08-23T00:24:24Z-
dc.date.issued2022-07-
dc.identifier.issn1340-3478-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/189415-
dc.description.abstractAims: Mismatches between the risk status of a patient and coronary imaging data can lead to conflicting strategies to prevent a cardiovascular event. We evaluated whether statin use was associated with cardiovascular benefit in high-risk individuals whose coronary computed tomography angiography (CCTA) results showed normal coronary arteries. Methods: Among asymptomatic individuals whose CCTA showed normal or near normal coronary arteries, 3,389 persons with high- or very-high-risk status were included in this retrospective study. After 1:2 propensity score matching, 906 individuals (302 new statin users and 604 controls; mean age 61 years; male 58%) were analysed. The primary outcome variable was major adverse cardiovascular and cerebrovascular events (MACCEs) that consisted of cardiovascular death, nonfatal myocardial infarction, coronary revascularisation, and nonfatal ischemic stroke. Results: At a median follow-up of 5.8 years, 20 statin users and 17 controls (7.4 and 5.6 events/1,000 person-year, respectively; hazard ratio [HR) 1.04; p=0.92) experienced MACCE. Kaplan-Meier curves showed similar MACCE rates in both groups (p=0.91). In separate analyses for persons with normal (p=0.29) or near normal coronary arteries (p=0.67), MACCE rates did not differ between the groups. Age (HR 1.04; p=0.044), male sex (HR 3.06, p=0.018), and smoking (HR 2.87, p=0.019) were independently associated with MACCEs. In subgroup analyses, no significant factors affected the relationship between statin use and MACCEs. Conclusions: Statin use was not associated with cardiovascular risk reduction in high-risk persons with normal or near normal coronary arteries. More individualised lipid-lowering therapy may benefit this population.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherJapan Atherosclerosis Society-
dc.relation.isPartOfJOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHComputed Tomography Angiography-
dc.subject.MESHCoronary Artery Disease* / drug therapy-
dc.subject.MESHCoronary Vessels / diagnostic imaging-
dc.subject.MESHHumans-
dc.subject.MESHHydroxymethylglutaryl-CoA Reductase Inhibitors* / therapeutic use-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMyocardial Infarction*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHTreatment Outcome-
dc.titleStatin Therapy in HIGH-Risk Individuals with NORMal Coronary Arteries: The HIGH-NORM Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorKyeong-Hyeon Chun-
dc.contributor.googleauthorJung Mi Park-
dc.contributor.googleauthorChan Joo Lee-
dc.contributor.googleauthorJaewon Oh-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorSang-Hak Lee-
dc.identifier.doi10.5551/jat.63004-
dc.contributor.localIdA00037-
dc.contributor.localIdA01512-
dc.contributor.localIdA02395-
dc.contributor.localIdA02833-
dc.contributor.localIdA03238-
dc.contributor.localIdA03500-
dc.relation.journalcodeJ01252-
dc.identifier.eissn1880-3873-
dc.identifier.pmid34334544-
dc.subject.keywordCoronary artery disease-
dc.subject.keywordHealth care-
dc.subject.keywordHydroxymethylglutaryl-CoA reductase inhibitors-
dc.subject.keywordOutcome assessment-
dc.subject.keywordRisk factors-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.affiliatedAuthor강석민-
dc.contributor.affiliatedAuthor박성하-
dc.contributor.affiliatedAuthor오재원-
dc.contributor.affiliatedAuthor이상학-
dc.contributor.affiliatedAuthor이찬주-
dc.contributor.affiliatedAuthor전경현-
dc.citation.volume29-
dc.citation.number7-
dc.citation.startPage1085-
dc.citation.endPage1094-
dc.identifier.bibliographicCitationJOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, Vol.29(7) : 1085-1094, 2022-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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