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Statin Therapy in HIGH-Risk Individuals with NORMal Coronary Arteries: The HIGH-NORM Study
DC Field | Value | Language |
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dc.contributor.author | 강석민 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 오재원 | - |
dc.contributor.author | 이상학 | - |
dc.contributor.author | 이찬주 | - |
dc.contributor.author | 전경현 | - |
dc.date.accessioned | 2022-08-23T00:24:24Z | - |
dc.date.available | 2022-08-23T00:24:24Z | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 1340-3478 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189415 | - |
dc.description.abstract | Aims: Mismatches between the risk status of a patient and coronary imaging data can lead to conflicting strategies to prevent a cardiovascular event. We evaluated whether statin use was associated with cardiovascular benefit in high-risk individuals whose coronary computed tomography angiography (CCTA) results showed normal coronary arteries. Methods: Among asymptomatic individuals whose CCTA showed normal or near normal coronary arteries, 3,389 persons with high- or very-high-risk status were included in this retrospective study. After 1:2 propensity score matching, 906 individuals (302 new statin users and 604 controls; mean age 61 years; male 58%) were analysed. The primary outcome variable was major adverse cardiovascular and cerebrovascular events (MACCEs) that consisted of cardiovascular death, nonfatal myocardial infarction, coronary revascularisation, and nonfatal ischemic stroke. Results: At a median follow-up of 5.8 years, 20 statin users and 17 controls (7.4 and 5.6 events/1,000 person-year, respectively; hazard ratio [HR) 1.04; p=0.92) experienced MACCE. Kaplan-Meier curves showed similar MACCE rates in both groups (p=0.91). In separate analyses for persons with normal (p=0.29) or near normal coronary arteries (p=0.67), MACCE rates did not differ between the groups. Age (HR 1.04; p=0.044), male sex (HR 3.06, p=0.018), and smoking (HR 2.87, p=0.019) were independently associated with MACCEs. In subgroup analyses, no significant factors affected the relationship between statin use and MACCEs. Conclusions: Statin use was not associated with cardiovascular risk reduction in high-risk persons with normal or near normal coronary arteries. More individualised lipid-lowering therapy may benefit this population. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Japan Atherosclerosis Society | - |
dc.relation.isPartOf | JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Computed Tomography Angiography | - |
dc.subject.MESH | Coronary Artery Disease* / drug therapy | - |
dc.subject.MESH | Coronary Vessels / diagnostic imaging | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydroxymethylglutaryl-CoA Reductase Inhibitors* / therapeutic use | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myocardial Infarction* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Statin Therapy in HIGH-Risk Individuals with NORMal Coronary Arteries: The HIGH-NORM Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Kyeong-Hyeon Chun | - |
dc.contributor.googleauthor | Jung Mi Park | - |
dc.contributor.googleauthor | Chan Joo Lee | - |
dc.contributor.googleauthor | Jaewon Oh | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.contributor.googleauthor | Sang-Hak Lee | - |
dc.identifier.doi | 10.5551/jat.63004 | - |
dc.contributor.localId | A00037 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A02395 | - |
dc.contributor.localId | A02833 | - |
dc.contributor.localId | A03238 | - |
dc.contributor.localId | A03500 | - |
dc.relation.journalcode | J01252 | - |
dc.identifier.eissn | 1880-3873 | - |
dc.identifier.pmid | 34334544 | - |
dc.subject.keyword | Coronary artery disease | - |
dc.subject.keyword | Health care | - |
dc.subject.keyword | Hydroxymethylglutaryl-CoA reductase inhibitors | - |
dc.subject.keyword | Outcome assessment | - |
dc.subject.keyword | Risk factors | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.affiliatedAuthor | 강석민 | - |
dc.contributor.affiliatedAuthor | 박성하 | - |
dc.contributor.affiliatedAuthor | 오재원 | - |
dc.contributor.affiliatedAuthor | 이상학 | - |
dc.contributor.affiliatedAuthor | 이찬주 | - |
dc.contributor.affiliatedAuthor | 전경현 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1085 | - |
dc.citation.endPage | 1094 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, Vol.29(7) : 1085-1094, 2022-07 | - |
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