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Effects of Iloprost on Arterial Oxygenation and Lung Mechanics during One-Lung Ventilation in Supine-Positioned Patients: A Randomized Controlled Study
DC Field | Value | Language |
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dc.contributor.author | 김남오 | - |
dc.contributor.author | 오영준 | - |
dc.contributor.author | 이규호 | - |
dc.date.accessioned | 2022-08-23T00:18:51Z | - |
dc.date.available | 2022-08-23T00:18:51Z | - |
dc.date.issued | 2022-06 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189366 | - |
dc.description.abstract | Patients undergoing one-lung ventilation (OLV) in the supine position face an increased risk of intraoperative hypoxia compared with those in the lateral decubitus position. We hypothesized that iloprost (ILO) inhalation improves arterial oxygenation and lung mechanics. Sixty-four patients were enrolled and allocated to either the ILO or control group (n = 32 each), to whom ILO or normal saline was administered. The partial pressure of the arterial oxygen/fraction of inspired oxygen (PaO2/FiO2) ratio, dynamic compliance, alveolar dead space, and hemodynamic variables were assessed 20 min after anesthesia induction with both lungs ventilated (T1) and 20 min after drug nebulization in OLV (T2). A linear mixed model adjusted for group and time was used to analyze repeated variables. While the alveolar dead space remained unchanged in the ILO group, it increased at T2 in the control group (n = 30 each) (p = 0.002). No significant differences were observed in the heart rate, mean blood pressure, PaO2/FiO2 ratio, or dynamic compliance in either group. Selective ILO nebulization was inadequate to enhance oxygenation parameters during OLV in the supine position. However, it favorably affected alveolar ventilation during OLV in supine-positioned patients without adverse hemodynamic effects. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | JOURNAL OF PERSONALIZED MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Effects of Iloprost on Arterial Oxygenation and Lung Mechanics during One-Lung Ventilation in Supine-Positioned Patients: A Randomized Controlled Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Kyuho Lee | - |
dc.contributor.googleauthor | Mina Kim | - |
dc.contributor.googleauthor | Namo Kim | - |
dc.contributor.googleauthor | Su Jeong Kang | - |
dc.contributor.googleauthor | Young Jun Oh | - |
dc.identifier.doi | 10.3390/jpm12071054 | - |
dc.contributor.localId | A00356 | - |
dc.contributor.localId | A02389 | - |
dc.contributor.localId | A06264 | - |
dc.relation.journalcode | J04078 | - |
dc.identifier.eissn | 2075-4426 | - |
dc.identifier.pmid | 35887551 | - |
dc.subject.keyword | iloprost | - |
dc.subject.keyword | lung mechanics | - |
dc.subject.keyword | one-lung ventilation | - |
dc.subject.keyword | oxygenation | - |
dc.subject.keyword | supine position | - |
dc.contributor.alternativeName | Kim, Namo | - |
dc.contributor.affiliatedAuthor | 김남오 | - |
dc.contributor.affiliatedAuthor | 오영준 | - |
dc.contributor.affiliatedAuthor | 이규호 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1054 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PERSONALIZED MEDICINE, Vol.12(7) : 1054, 2022-06 | - |
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