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Postmastectomy Radiation Therapy for Node-Negative Breast Cancer of 5 cm or Larger Tumors: A Multicenter Retrospective Analysis (KROG 20-03)

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dc.contributor.author김용배-
dc.contributor.author이익재-
dc.contributor.author장지석-
dc.date.accessioned2022-08-23T00:15:20Z-
dc.date.available2022-08-23T00:15:20Z-
dc.date.issued2022-04-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/189336-
dc.description.abstractPurpose: To evaluate the role of postmastectomy radiation therapy (PMRT) in patients with node-negative breast cancer of 5cm or larger tumors undergoing mastectomy. Materials and methods: Medical records of 274 patients from 18 institutions treated with mastectomy between January 2000 and December 2016 were retrospectively reviewed. Among these, 202 patients underwent PMRT, while 72 did not. Two hundred and forty-one patients (88.0%) received systemic chemotherapy, and 172 (62.8%) received hormonal therapy. Patients receiving PMRT were younger, more likely to have progesterone receptor-positive tumors, and received adjuvant chemotherapy more frequently compared with those without PMRT (p <0.001, 0.018, and <0.001, respectively). Other characteristics were not significantly different between the two groups. Results: With a median follow-up of 95 months (range, 1-249), there were 9 locoregional recurrences, and 20 distant metastases. The 8-year locoregional recurrence-free survival rates were 98.0% with PMRT and 91.3% without PMRT (p=0.133), and the 8-year disease-free survival (DFS) rates were 91.8% with PMRT and 73.9% without PMRT (p=0.008). On multivariate analysis incorporating age, histologic grade, lymphovascular invasion, hormonal therapy, chemotherapy, and PMRT, the absence of lymphovascular invasion and the receipt of PMRT were associated with improved DFS (p=0.025 and 0.009, respectively). Conclusion: Locoregional recurrence rate was very low in node-negative breast cancer of 5cm or larger tumors treated with mastectomy regardless of the receipt of PMRT. However, PMRT was significantly associated with improved DFS. Further investigation is needed to confirm these findings.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish, Korean-
dc.publisherOfficial journal of Korean Cancer Association-
dc.relation.isPartOfCANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHBreast Neoplasms* / radiotherapy-
dc.subject.MESHBreast Neoplasms* / surgery-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMastectomy-
dc.subject.MESHNeoplasm Recurrence, Local / pathology-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHRadiotherapy, Adjuvant-
dc.subject.MESHRetrospective Studies-
dc.titlePostmastectomy Radiation Therapy for Node-Negative Breast Cancer of 5 cm or Larger Tumors: A Multicenter Retrospective Analysis (KROG 20-03)-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorKyubo Kim-
dc.contributor.googleauthorJinhong Jung-
dc.contributor.googleauthorHaeyoung Kim-
dc.contributor.googleauthorWonguen Jung-
dc.contributor.googleauthorKyung Hwan Shin-
dc.contributor.googleauthorJi Hyun Chang-
dc.contributor.googleauthorSu Ssan Kim-
dc.contributor.googleauthorWon Park-
dc.contributor.googleauthorJee Suk Chang-
dc.contributor.googleauthorYong Bae Kim-
dc.contributor.googleauthorSung Ja Ahn-
dc.contributor.googleauthorIk Jae Lee-
dc.contributor.googleauthorJong Hoon Lee-
dc.contributor.googleauthorHae Jin Park-
dc.contributor.googleauthorJihye Cha-
dc.contributor.googleauthorJuree Kim-
dc.contributor.googleauthorJin Hwa Choi-
dc.contributor.googleauthorTaeryool Koo-
dc.contributor.googleauthorJeanny Kwon-
dc.contributor.googleauthorJin Hee Kim-
dc.contributor.googleauthorMi Young Kim-
dc.contributor.googleauthorShin-Hyung Park-
dc.contributor.googleauthorYeon-Joo Kim-
dc.identifier.doi10.4143/crt.2021.933-
dc.contributor.localIdA00744-
dc.contributor.localIdA03055-
dc.contributor.localIdA04658-
dc.relation.journalcodeJ00453-
dc.identifier.eissn2005-9256-
dc.identifier.pmid34445845-
dc.subject.keywordBreast neoplasms-
dc.subject.keywordMastectomy-
dc.subject.keywordNode-negative-
dc.subject.keywordRadiotherapy-
dc.subject.keyword≥5cm-
dc.contributor.alternativeNameKim, Yong Bae-
dc.contributor.affiliatedAuthor김용배-
dc.contributor.affiliatedAuthor이익재-
dc.contributor.affiliatedAuthor장지석-
dc.citation.volume54-
dc.citation.number2-
dc.citation.startPage497-
dc.citation.endPage504-
dc.identifier.bibliographicCitationCANCER RESEARCH AND TREATMENT, Vol.54(2) : 497-504, 2022-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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