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Derivation and Validation of a New Disease Activity Assessment Tool With Higher Accuracy for Takayasu Arteritis
DC Field | Value | Language |
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dc.contributor.author | 권오찬 | - |
dc.contributor.author | 박민찬 | - |
dc.date.accessioned | 2022-08-23T00:13:37Z | - |
dc.date.available | 2022-08-23T00:13:37Z | - |
dc.date.issued | 2022-06 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189320 | - |
dc.description.abstract | Objective: To develop a new disease activity assessment tool with high accuracy for Takayasu arteritis. Methods: Individual items from National Institute of Health (NIH) criteria and the Indian Takayasu Clinical Activity Score (ITAS2010) were tested as candidate variables to develop a new disease activity assessment tool in a derivation cohort (N = 100). Physician global assessment on disease activity was used as the gold standard. Multivariable logistic regression models were constructed and the model with the highest accuracy was identified. A formula assessing disease activity was generated using simplified β coefficients (rounded to decimal place). Diagnostic performance was evaluated through estimating the area under the curve (AUC). The new assessment tool was subsequently validated in a validation cohort (N = 46). Results: The multivariable model yielding the highest accuracy consisted of a high erythrocyte sedimentation rate (ESR), NIH criteria 1 and 4, and carotidynia. Using simplified β coefficients, the following disease activity assessment tool was developed: high ESR (3 points), NIH criterion 1 (2 points), NIH criterion 4 (4 points), and carotidynia (3 points) (total score ≥5, active; total score <5, inactive). The new disease activity assessment tool had a higher AUC (89.37) for discriminating active and inactive diseases than NIH criteria (AUC 77.96), ITAS2010 (AUC 66.12), ITAS-ESR (AUC 75.58), and ITAS-C-reactive protein (AUC 71.34). The AUC (85.23) of the new assessment tool was similar in the validation cohort. Conclusion: A new disease activity assessment tool that consists of high ESR, NIH criteria 1 and 4, and carotidynia had higher accuracy in discriminating active and inactive disease than currently used clinical assessment tools. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Frontiers Research Foundation | - |
dc.relation.isPartOf | FRONTIERS IN IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Area Under Curve | - |
dc.subject.MESH | Asians | - |
dc.subject.MESH | Autonomic Nervous System Diseases* | - |
dc.subject.MESH | C-Reactive Protein | - |
dc.subject.MESH | Carotid Artery Diseases* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Takayasu Arteritis* / diagnosis | - |
dc.title | Derivation and Validation of a New Disease Activity Assessment Tool With Higher Accuracy for Takayasu Arteritis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Oh Chan Kwon | - |
dc.contributor.googleauthor | Min-Chan Park | - |
dc.identifier.doi | 10.3389/fimmu.2022.925341 | - |
dc.contributor.localId | A05818 | - |
dc.contributor.localId | A01470 | - |
dc.relation.journalcode | J03075 | - |
dc.identifier.eissn | 1664-3224 | - |
dc.identifier.pmid | 35784279 | - |
dc.subject.keyword | Takayasu arteritis | - |
dc.subject.keyword | accuracy | - |
dc.subject.keyword | assessment | - |
dc.subject.keyword | disease activity | - |
dc.subject.keyword | vasculitis | - |
dc.contributor.alternativeName | Kwon, Oh Chan | - |
dc.contributor.affiliatedAuthor | 권오찬 | - |
dc.contributor.affiliatedAuthor | 박민찬 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 925341 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN IMMUNOLOGY, Vol.13(1) : 925341, 2022-06 | - |
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