Cited 10 times in
Prognostic Factors in Early-stage NSCLC: Analysis of the Placebo Group in the MAGRIT Study
DC Field | Value | Language |
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dc.contributor.author | 조병철 | - |
dc.date.accessioned | 2022-08-19T06:32:22Z | - |
dc.date.available | 2022-08-19T06:32:22Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189263 | - |
dc.description.abstract | Background/Aim: The analysis of prognostic factors is important to identify determinants of disease-free survival (DFS) and overall survival (OS) in resected non-small-cell lung cancer (NSCLC). Patients and Methods: We examined baseline characteristics associated with DFS and OS among 757 patients with resected, histologically proven, MAGE-A3-positive Stage IB-IIIA NSCLC assigned to placebo in the MAGRIT study (NCT00480025). We explored characteristics of NSCLC that could predict DFS and OS using Cox regression models. Results: The multivariate analysis showed that lower nodal stage, the presence of squamous cell carcinoma (SCC), a broader surgical resection in patients with SCC, and being female with non-SCC were significantly associated with longer DFS. Lower nodal stage and smaller tumor size were significantly associated with an improved OS. Compared to Other International, enrollment in East Asia was associated with an improved OS in patients with non-SCC. Conclusion: This is the first prognostic factor analysis in NSCLC performed on data from a large prospective study. These results confirm retrospective studies and add that histopathology subtype is a strong determinant of DFS in resected MAGE-A3-positive NSCLC. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | International Institute of Anticancer Research | - |
dc.relation.isPartOf | ANTICANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung / pathology* | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lung Neoplasms / pathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Placebos | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Survival Analysis | - |
dc.title | Prognostic Factors in Early-stage NSCLC: Analysis of the Placebo Group in the MAGRIT Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Byoung Chul Cho | - |
dc.contributor.googleauthor | Tommaso DE Pas | - |
dc.contributor.googleauthor | Haralabos Kalofonos | - |
dc.contributor.googleauthor | Qun Wang | - |
dc.contributor.googleauthor | Rodryg Ramlau | - |
dc.contributor.googleauthor | Ying Cheng | - |
dc.contributor.googleauthor | Fabiana Vitiello | - |
dc.contributor.googleauthor | Tanel Laisaar | - |
dc.contributor.googleauthor | Eric Vallières | - |
dc.contributor.googleauthor | Bartosz Kubisa | - |
dc.contributor.googleauthor | Sergey Orlov | - |
dc.contributor.googleauthor | Keunchil Park | - |
dc.contributor.googleauthor | Channa Debruyne | - |
dc.contributor.googleauthor | Johan Vansteenkiste | - |
dc.identifier.doi | 10.21873/anticanres.13255 | - |
dc.contributor.localId | A03822 | - |
dc.relation.journalcode | J00188 | - |
dc.identifier.eissn | 1791-7530 | - |
dc.identifier.pmid | 30842175 | - |
dc.identifier.url | https://ar.iiarjournals.org/content/39/3/1403.long | - |
dc.subject.keyword | Non-small cell lung cancer | - |
dc.subject.keyword | MAGE-A3 cancer immunotherapeutic | - |
dc.subject.keyword | prognostic factors | - |
dc.subject.keyword | placebo | - |
dc.subject.keyword | overall survival | - |
dc.contributor.alternativeName | Cho, Byoung Chul | - |
dc.contributor.affiliatedAuthor | 조병철 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1403 | - |
dc.citation.endPage | 1409 | - |
dc.identifier.bibliographicCitation | ANTICANCER RESEARCH, Vol.39(3) : 1403-1409, 2019-03 | - |
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