Cited 14 times in
Comparative efficacy of various anti-ulcer medications after gastric endoscopic submucosal dissection: a systematic review and network meta-analysis
DC Field | Value | Language |
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dc.contributor.author | 김은혜 | - |
dc.date.accessioned | 2022-08-19T06:31:04Z | - |
dc.date.available | 2022-08-19T06:31:04Z | - |
dc.date.issued | 2019-04 | - |
dc.identifier.issn | 0930-2794 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189243 | - |
dc.description.abstract | BackgroundThe comparative efficacy of various anti-ulcer medications after gastric endoscopic submucosal dissection (ESD) has not been fully evaluated. Recently, vonoprazan, a novel potassium-competitive acid blocker, has also been used in ulcer treatment after ESD.MethodsWe searched for all relevant randomized controlled trials examining the efficacy of anti-ulcer medications after gastric ESD, published through October 2017. Healing of iatrogenic ulcers was investigated at 4-8weeks after ESD. A network meta-analysis was performed to calculate the network estimates.ResultsTwenty-one studies with 2005 patients were included. Concerning the comparative efficacy for ulcer healing at 4weeks after ESD, no network inconsistency was identified (Cochran's Q-test, df=10, P=0.13; I-2=34%). A combination therapy of proton-pump inhibitor (PPI) and muco-protective agent was superior to PPI alone [risk ratio (RR) (95% confidence interval, CI) 1.69 (1.20-2.39)]. The combination therapy of PPI and muco-protective agents tended to be superior to vonoprazan [RR (95% CI) 1.98 (0.99-3.94)]. There was no difference of ulcer healing effect between PPI and vonoprazan [RR (95% CI) PPI vs. vonoprazan, 1.17 (0.64-2.12)]. Concerning the ulcer healing rate at 8weeks after ESD, however, vonoprazan was superior to PPI [RR (95% CI) 1.27 (1.03-1.56)]. Additionally, vonoprazan tended to be superior to the combination therapy of PPI and muco-protective agent [RR (95% CI) 1.20 (0.96-1.51)].ConclusionsA combination therapy of PPI and muco-protective agent was superior to PPI alone for ulcer healing at 4weeks after ESD. In the ulcer healing effect at 8weeks after ESD, vonoprazan was superior to PPI. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Anti-Ulcer Agents / therapeutic use* | - |
dc.subject.MESH | Endoscopic Mucosal Resection* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Network Meta-Analysis | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Proton Pump Inhibitors / therapeutic use | - |
dc.subject.MESH | Pyrroles / therapeutic use | - |
dc.subject.MESH | Stomach Neoplasms / surgery* | - |
dc.subject.MESH | Stomach Ulcer / drug therapy* | - |
dc.subject.MESH | Stomach Ulcer / prevention & control | - |
dc.subject.MESH | Sulfonamides / therapeutic use | - |
dc.subject.MESH | Wound Healing / drug effects | - |
dc.title | Comparative efficacy of various anti-ulcer medications after gastric endoscopic submucosal dissection: a systematic review and network meta-analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Eun Hye Kim | - |
dc.contributor.googleauthor | Se Woo Park | - |
dc.contributor.googleauthor | Eunwoo Nam | - |
dc.contributor.googleauthor | Jae Gon Lee | - |
dc.contributor.googleauthor | Chan Hyuk Park | - |
dc.identifier.doi | 10.1007/s00464-018-6409-4 | - |
dc.contributor.localId | A00827 | - |
dc.relation.journalcode | J02703 | - |
dc.identifier.eissn | 1432-2218 | - |
dc.identifier.pmid | 30167955 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s00464-018-6409-4 | - |
dc.subject.keyword | Endoscopic submucosal dissection | - |
dc.subject.keyword | Anti-ulcer medication | - |
dc.subject.keyword | Proton-pump inhibitor | - |
dc.subject.keyword | Vonoprazan | - |
dc.contributor.alternativeName | Kim, Eun Hye | - |
dc.contributor.affiliatedAuthor | 김은혜 | - |
dc.citation.volume | 33 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1271 | - |
dc.citation.endPage | 1283 | - |
dc.identifier.bibliographicCitation | SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol.33(4) : 1271-1283, 2019-04 | - |
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