Cited 24 times in
Gastric cancer depends on aldehyde dehydrogenase 3A1 for fatty acid oxidation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정재호 | - |
dc.date.accessioned | 2022-08-19T06:30:36Z | - |
dc.date.available | 2022-08-19T06:30:36Z | - |
dc.date.issued | 2019-11 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189235 | - |
dc.description.abstract | The major source of ATP in cancer cells remains unclear. Here, we examined energy metabolism in gastric cancer cells and found increased fatty acid oxidation and increased expression of ALDH3A1. Metabolic analysis showed that lipid peroxidation by reactive oxygen species led to spontaneous production of 4-hydroxynonenal, which was converted to fatty acids with NADH production by ALDH3A1, resulting in further fatty acid oxidation. Inhibition of ALDH3A1 by knock down using siRNA of ALDH3A1 resulted in significantly reduced ATP production by cancer cells, leading to apoptosis. Oxidative phosphorylation by mitochondria in gastric cancer cells was driven by NADH supplied via fatty acid oxidation. Therefore, blockade of ALDH3A1 together with mitochondrial complex I using gossypol and phenformin led to significant therapeutic effects in a preclinical gastric cancer model. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adenosine Triphosphate / biosynthesis | - |
dc.subject.MESH | Aldehyde Dehydrogenase / deficiency | - |
dc.subject.MESH | Aldehyde Dehydrogenase / genetics | - |
dc.subject.MESH | Aldehyde Dehydrogenase / metabolism* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Proliferation / drug effects | - |
dc.subject.MESH | Fatty Acids / metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Knockdown Techniques | - |
dc.subject.MESH | Gossypol / pharmacology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Oxidation-Reduction | - |
dc.subject.MESH | Phenformin / pharmacology | - |
dc.subject.MESH | Stomach Neoplasms / metabolism* | - |
dc.subject.MESH | Stomach Neoplasms / pathology | - |
dc.title | Gastric cancer depends on aldehyde dehydrogenase 3A1 for fatty acid oxidation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Jae-Seon Lee | - |
dc.contributor.googleauthor | Seung Hwa Kim | - |
dc.contributor.googleauthor | Soohyun Lee | - |
dc.contributor.googleauthor | Joon Hee Kang | - |
dc.contributor.googleauthor | Seon-Hyeong Lee | - |
dc.contributor.googleauthor | Jae-Ho Cheong | - |
dc.contributor.googleauthor | Soo-Youl Kim | - |
dc.identifier.doi | 10.1038/s41598-019-52814-1 | - |
dc.contributor.localId | A03717 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 31705020 | - |
dc.contributor.alternativeName | Cheong, Jae Ho | - |
dc.contributor.affiliatedAuthor | 정재호 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 16313 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.9(1) : 16313, 2019-11 | - |
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