Cited 7 times in
An Outbreak of KPC-Producing Klebsiella pneumoniae Linked with an Index Case of Community-Acquired KPC-Producing Isolate: Epidemiological Investigation and Whole Genome Sequencing Analysis
DC Field | Value | Language |
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dc.contributor.author | 구남수 | - |
dc.contributor.author | 김준명 | - |
dc.contributor.author | 송제은 | - |
dc.contributor.author | 용동은 | - |
dc.contributor.author | 이경원 | - |
dc.contributor.author | 정수진 | - |
dc.contributor.author | 정우용 | - |
dc.contributor.author | 정인영 | - |
dc.contributor.author | 최준용 | - |
dc.contributor.author | 최흔 | - |
dc.date.accessioned | 2022-08-19T06:27:47Z | - |
dc.date.available | 2022-08-19T06:27:47Z | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 1076-6294 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189198 | - |
dc.description.abstract | Aims: A hospital outbreak of Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPN) linked with an index case of community-acquired infection occurred in an urban tertiary care hospital in Seoul, South Korea. Therefore, we performed an outbreak investigation and whole genome sequencing (WGS) analysis to trace the outbreak and investigate the molecular characteristics of the isolates. Results: From October 2014 to January 2015, we identified a cluster of three patients in the neurosurgery ward with sputum cultures positive for carbapenem-resistant KPN. An epidemiological investigation, including pulsed-field gel electrophoresis analysis was performed to trace the origins of this outbreak. The index patient's infection was community acquired. Active surveillance cultures using perirectal swabbing from exposed patients, identified one additional patient with KPC-producing KPN colonization. WGS analyses using PacBio RSII instruments were performed for four linked isolates. WGS revealed a genetic linkage of the four isolates belonging to the same sequence type (ST307). All KPN isolates harbored conjugative resistance plasmids, which has bla(KPC-2) carbapenemase genes contained within the Tn4401 "a" isoform and other resistance genes. However, WGS showed only three isolates among four KPC-producing KPN were originated from a common origin. Conclusions: This report demonstrates the challenge that KPC-2-producing KPN with the conjugative resistance plasmid may spread not only in hospitals but also in community, and WGS can help to accurately characterize the outbreak. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Mary Ann Liebert | - |
dc.relation.isPartOf | MICROBIAL DRUG RESISTANCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Anti-Bacterial Agents / pharmacology | - |
dc.subject.MESH | Bacterial Proteins / genetics | - |
dc.subject.MESH | Community-Acquired Infections / epidemiology* | - |
dc.subject.MESH | Community-Acquired Infections / microbiology | - |
dc.subject.MESH | Disease Outbreaks* | - |
dc.subject.MESH | Drug Resistance, Bacterial / genetics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Klebsiella Infections / epidemiology* | - |
dc.subject.MESH | Klebsiella Infections / microbiology | - |
dc.subject.MESH | Klebsiella pneumoniae / genetics | - |
dc.subject.MESH | Klebsiella pneumoniae / isolation & purification* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Plasmids / genetics | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Sputum / microbiology | - |
dc.subject.MESH | Tertiary Care Centers | - |
dc.subject.MESH | Whole Genome Sequencing | - |
dc.subject.MESH | beta-Lactamases / genetics | - |
dc.title | An Outbreak of KPC-Producing Klebsiella pneumoniae Linked with an Index Case of Community-Acquired KPC-Producing Isolate: Epidemiological Investigation and Whole Genome Sequencing Analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Je Eun Song | - |
dc.contributor.googleauthor | Haeyoung Jeong | - |
dc.contributor.googleauthor | Young Sun Lim | - |
dc.contributor.googleauthor | Eun Jin Ha | - |
dc.contributor.googleauthor | In Young Jung | - |
dc.contributor.googleauthor | Wooyong Jeong | - |
dc.contributor.googleauthor | Heun Choi | - |
dc.contributor.googleauthor | Su Jin Jeong | - |
dc.contributor.googleauthor | Nam Su Ku | - |
dc.contributor.googleauthor | Eun Suk Park | - |
dc.contributor.googleauthor | Dongeun Yong | - |
dc.contributor.googleauthor | Kyungwon Lee | - |
dc.contributor.googleauthor | June Myung Kim | - |
dc.contributor.googleauthor | Jun Yong Choi | - |
dc.identifier.doi | 10.1089/mdr.2018.0475 | - |
dc.contributor.localId | A00189 | - |
dc.contributor.localId | A00953 | - |
dc.contributor.localId | A02059 | - |
dc.contributor.localId | A02423 | - |
dc.contributor.localId | A02649 | - |
dc.contributor.localId | A03638 | - |
dc.contributor.localId | A04670 | - |
dc.contributor.localId | A03695 | - |
dc.contributor.localId | A04191 | - |
dc.contributor.localId | A04227 | - |
dc.relation.journalcode | J02229 | - |
dc.identifier.eissn | 1931-8448 | - |
dc.identifier.pmid | 31334673 | - |
dc.identifier.url | https://www.liebertpub.com/doi/10.1089/mdr.2018.0475 | - |
dc.subject.keyword | Klebsiella pneumoniae carbapenemase | - |
dc.subject.keyword | outbreak | - |
dc.subject.keyword | whole genome sequencing analysis | - |
dc.contributor.alternativeName | Ku, Nam Su | - |
dc.contributor.affiliatedAuthor | 구남수 | - |
dc.contributor.affiliatedAuthor | 김준명 | - |
dc.contributor.affiliatedAuthor | 송제은 | - |
dc.contributor.affiliatedAuthor | 용동은 | - |
dc.contributor.affiliatedAuthor | 이경원 | - |
dc.contributor.affiliatedAuthor | 정수진 | - |
dc.contributor.affiliatedAuthor | 정우용 | - |
dc.contributor.affiliatedAuthor | 정인영 | - |
dc.contributor.affiliatedAuthor | 최준용 | - |
dc.contributor.affiliatedAuthor | 최흔 | - |
dc.citation.volume | 25 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1475 | - |
dc.citation.endPage | 1483 | - |
dc.identifier.bibliographicCitation | MICROBIAL DRUG RESISTANCE, Vol.25(10) : 1475-1483, 2019-12 | - |
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