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The expressions of autotaxin-lysophosphatidate signaling-related proteins in metastatic breast cancer
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.date.accessioned | 2022-08-19T06:25:16Z | - |
dc.date.available | 2022-08-19T06:25:16Z | - |
dc.date.issued | 2019-08 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189155 | - |
dc.description.abstract | Purpose: We evaluated the expression of autotaxin-lysophosphatidate signaling-related proteins and the clinical implications for metastatic breast cancer. Methods: We constructed tissue microarrays (TMA) with 126 cases of metastatic breast cancer [31 (24.6%) bone metastases, 36 (28.6%) brain metastases, 11 (8.7%) liver metastases, and 48 (38.1%) lung metastasis], and we conducted immunohistochemical staining for the autotoxin-lysophosphatidate signaling-related proteins ATX, LPA1, LPA2, and LPA3. Results: Stromal ATX (P = 0.006) and LPA1 (P < 0.001) were differently expressed according to their metastatic organ; stromal ATX showed high expression in bone metastasis, and LPA1 showed high expression in liver and lung metastases. Stromal ATX positivity was higher than others in luminal A type tumors (P = 0.035), and stromal LPA3 positivity was correlated with a high Ki-67 labeling index (U) (P = 0.005). In univariate analysis, tumoral LPA3 negativity was correlated with shorter overall survival (OS) ( P = 0.015) in metastatic breast cancer. When analyzed according to the metastatic sites, tumoral LPA3 negativity was correlated with shorter OS (P = 0.010) in lung metastasis, whereas stromal LPA3 negativity was correlated with shorter OS (P = 0.026) in brain metastasis. In multivariate Cox analysis, tumoral LPA3 negativity was an independent poor prognostic factor (HR = 2.311, 95% CI: 1.029-5.191, P = 0.043). Conclusion: Among autotoxin-lysophosphatidate signaling-related proteins, stromal ATX was highly expressed in bone metastases, and LPA1 was highly expressed in liver and lung metastases. Tumoral LPA3 might be a prognostic factor in metastatic breast cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | e-Century Pub. Corp. | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | The expressions of autotaxin-lysophosphatidate signaling-related proteins in metastatic breast cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Su Jung Shim | - |
dc.contributor.googleauthor | Eunah Shin | - |
dc.contributor.googleauthor | Choong-Sik Lee | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.contributor.localId | A00198 | - |
dc.relation.journalcode | J01096 | - |
dc.identifier.eissn | 1936-2625 | - |
dc.identifier.pmid | 31934128 | - |
dc.subject.keyword | Autotaxin | - |
dc.subject.keyword | breast cancer | - |
dc.subject.keyword | lysophosphatidate receptor | - |
dc.subject.keyword | metastasis | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2920 | - |
dc.citation.endPage | 2930 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, Vol.12(8) : 2920-2930, 2019-08 | - |
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