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Brain Iron Accumulation in Atypical Parkinsonian Syndromes: in vivo MRI Evidences for Distinctive Patterns
DC Field | Value | Language |
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dc.contributor.author | 이명식 | - |
dc.date.accessioned | 2022-08-19T06:24:36Z | - |
dc.date.available | 2022-08-19T06:24:36Z | - |
dc.date.issued | 2019-02 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189144 | - |
dc.description.abstract | Recent data suggest mechanistic links among perturbed iron homeostasis, oxidative stress, and misfolded protein aggregation in neurodegenerative diseases. Iron overload and toxicity toward dopaminergic neurons have been established as playing a role in the pathogenesis of Parkinson's disease (PD). Brain iron accumulation has also been documented in atypical parkinsonian syndromes (APS), mainly comprising multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). Iron-sensitive magnetic resonance imaging (MRI) has been applied to identify iron-related signal changes for the diagnosis and differentiation of these disorders. Topographic patterns of widespread iron deposition in deep brain nuclei have been described as differing between patients with MSA and PSP and those with PD. A disease-specific increase of iron occurs in the brain regions mainly affected by underlying disease pathologies. However, whether iron changes are a primary pathogenic factor or an epiphenomenon of neuronal degeneration has not been fully elucidated. Moreover, the clinical implications of iron-related pathology in APS remain unclear. In this review study, we collected data from qualitative and quantitative MRI studies on brain iron accumulation in APS to identify disease-related patterns and the potential role of iron-sensitive MRI. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Frontiers Research Foundation | - |
dc.relation.isPartOf | FRONTIERS IN NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Brain Iron Accumulation in Atypical Parkinsonian Syndromes: in vivo MRI Evidences for Distinctive Patterns | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Jae-Hyeok Lee | - |
dc.contributor.googleauthor | Myung-Sik Lee | - |
dc.identifier.doi | 10.3389/fneur.2019.00074 | - |
dc.contributor.localId | A02753 | - |
dc.relation.journalcode | J02996 | - |
dc.identifier.eissn | 1664-2295 | - |
dc.identifier.pmid | 30809185 | - |
dc.subject.keyword | iron | - |
dc.subject.keyword | neurodegeneration | - |
dc.subject.keyword | magnetic resonance imaging | - |
dc.subject.keyword | atypical parkinsonian syndromes | - |
dc.subject.keyword | multiple system atrophy | - |
dc.subject.keyword | progressive supranuclear palsy | - |
dc.contributor.alternativeName | Lee, Myung Sik | - |
dc.contributor.affiliatedAuthor | 이명식 | - |
dc.citation.volume | 10 | - |
dc.citation.startPage | 74 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN NEUROLOGY, Vol.10 : 74, 2019-02 | - |
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