Cited 43 times in
Mitochondria-centric bioenergetic characteristics in cancer stem-like cells
DC Field | Value | Language |
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dc.contributor.author | 정재호 | - |
dc.date.accessioned | 2022-08-19T06:22:30Z | - |
dc.date.available | 2022-08-19T06:22:30Z | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189105 | - |
dc.description.abstract | Metabolic and genotoxic stresses that arise during tumor progression and anti-cancer treatment, respectively, can impose a selective pressure to promote cancer evolution in the tumor microenvironment. This process ultimately selects for the most fit clones, which generally have a cancer stem cell like phenotype with features of drug resistance, epithelial-mesenchymal transition, invasiveness, and high metastatic potential. From a bioenergetics perspective, these cancer stem-like cells (CSCs) exhibit mitochondria-centric energy metabolism and are capable of opportunistically utilizing available nutrients such as fatty acids to generate ATP and other metabolic substances, providing a selective advantage for their survival in an impermissible environment and metabolic context. Thus, diverse therapeutic strategies are needed to efficiently tackle these CSCs and eliminate their advantage. Here, we review the metabolic and bioenergetic characteristics and vulnerabilities specific to CSCs, which can provide an unprecedented opportunity to curb CSC-driven cancer mortality rates. We particularly focus on the potential of a CSC bioenergetics-targeted strategy as a versatile therapeutic component of treatment modalities applicable to most cancer types. A cancer bioenergetics-targeted strategy can expand the inventory of combinatorial regimens in the current anti-cancer armamentarium. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Pharmaceutical Society of Korea | - |
dc.relation.isPartOf | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antineoplastic Agents / pharmacology | - |
dc.subject.MESH | Energy Metabolism / drug effects | - |
dc.subject.MESH | Energy Metabolism / physiology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mitochondria / drug effects | - |
dc.subject.MESH | Mitochondria / metabolism* | - |
dc.subject.MESH | Neoplastic Stem Cells / drug effects | - |
dc.subject.MESH | Neoplastic Stem Cells / metabolism* | - |
dc.subject.MESH | Oxidative Stress / drug effects | - |
dc.subject.MESH | Oxidative Stress / physiology | - |
dc.subject.MESH | Tumor Microenvironment / drug effects | - |
dc.subject.MESH | Tumor Microenvironment / physiology* | - |
dc.title | Mitochondria-centric bioenergetic characteristics in cancer stem-like cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Min-Kyue Shin | - |
dc.contributor.googleauthor | Jae-Ho Cheong | - |
dc.identifier.doi | 10.1007/s12272-019-01127-y | - |
dc.contributor.localId | A03717 | - |
dc.relation.journalcode | J00229 | - |
dc.identifier.pmid | 30771209 | - |
dc.subject.keyword | Bioenergetics | - |
dc.subject.keyword | Cancer metabolism | - |
dc.subject.keyword | Cancer evolution | - |
dc.subject.keyword | Cancer stem cell | - |
dc.subject.keyword | Mitochondria | - |
dc.subject.keyword | Fatty acid oxidation | - |
dc.subject.keyword | -Oxidation | - |
dc.contributor.alternativeName | Cheong, Jae Ho | - |
dc.contributor.affiliatedAuthor | 정재호 | - |
dc.citation.volume | 42 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 113 | - |
dc.citation.endPage | 127 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, Vol.42(2) : 113-127, 2019-02 | - |
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