Cited 2 times in
Effect of Renin - Angiotensin - Aldosterone System Blockade on Outcomes in Patients With ESRD: A Prospective Cohort Study in Korea
DC Field | Value | Language |
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dc.contributor.author | 강신욱 | - |
dc.date.accessioned | 2022-08-16T01:33:13Z | - |
dc.date.available | 2022-08-16T01:33:13Z | - |
dc.date.issued | 2018-08 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188940 | - |
dc.description.abstract | Introduction: Conflicting results still exist regarding the benefit of renin-angiotensin-aldosterone system (RAAS) blockade on clinical outcomes in dialysis patients. The aim of this study was to evaluate the effects of RAAS blockade on survival in Korean patients with end-stage renal disease (ESRD). Methods: Our analysis was based on the data of 5223 patients enrolled from the Clinical Research Center for ESRD, a nationwide prospective observational cohort. Multivariate Cox regression was applied for risk factor analysis with the cumulative duration of RAAS blockade use as time-varying covariate. The risks for mortality from all causes and major cardiovascular event-free survival were estimated. Results: Compared to the control group, patients in the RAAS group were younger but had a higher proportion of diabetes mellitus, had higher systolic blood pressure, required a greater number of prescribed antihypertensive drugs, and had a longer dialysis duration. On multivariate time-varying Cox regression analysis, the RAAS group with cumulative duration of >90 days was significantly associated with a lower risk of mortality from all causes after adjustment for confounding (hazard ratio [HR] = 0.45, 95% confidence interval [CI] = 0.35-0.58, P < 0.0001). Major cardiovascular event-free survival was also better for the RAAS group than for the control group on multivariate analysis (HR = 0.27, 95% CI = 0.20-0.37, P < 0.0001), considering the cumulative duration of RAAS blockade use. Conclusion: In Korean patients with ESRD, we reported a specific benefit of RAAS blockade in improving overall survival after adjustment for confounding factors from real-world data. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | KIDNEY INTERNATIONAL REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Effect of Renin - Angiotensin - Aldosterone System Blockade on Outcomes in Patients With ESRD: A Prospective Cohort Study in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Kyung Don Yoo | - |
dc.contributor.googleauthor | Clara Tammy Kim | - |
dc.contributor.googleauthor | Yunmi Kim | - |
dc.contributor.googleauthor | Hyo Jin Kim | - |
dc.contributor.googleauthor | Jae Yoon Park | - |
dc.contributor.googleauthor | Ji In Park | - |
dc.contributor.googleauthor | Yun Kyu Oh | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.contributor.googleauthor | Chul Woo Yang | - |
dc.contributor.googleauthor | Yong-Lim Kim | - |
dc.contributor.googleauthor | Yon Su Kim | - |
dc.contributor.googleauthor | Chun Soo Lim | - |
dc.contributor.googleauthor | Jung Pyo Lee | - |
dc.identifier.doi | 10.1016/j.ekir.2018.07.023 | - |
dc.contributor.localId | A00053 | - |
dc.relation.journalcode | J03884 | - |
dc.identifier.eissn | 2468-0249 | - |
dc.identifier.pmid | 30450465 | - |
dc.subject.keyword | ACE inhibitor | - |
dc.subject.keyword | ARB | - |
dc.subject.keyword | ESRD | - |
dc.subject.keyword | dialysis | - |
dc.subject.keyword | mortality | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | 강신욱 | - |
dc.citation.volume | 3 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1385 | - |
dc.citation.endPage | 1393 | - |
dc.identifier.bibliographicCitation | KIDNEY INTERNATIONAL REPORTS, Vol.3(6) : 1385-1393, 2018-08 | - |
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