Cited 8 times in
Herpes Zoster DNA Vaccines with IL-7 and IL-33 Molecular Adjuvants Elicit Protective T Cell Immunity
DC Field | Value | Language |
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dc.contributor.author | 김종훈 | - |
dc.date.accessioned | 2022-08-05T06:06:01Z | - |
dc.date.available | 2022-08-05T06:06:01Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188864 | - |
dc.description.abstract | Herpes zoster (HZ), or shingles, is caused by the reactivation of latent varicella-zoster virus (VZV) from the sensory ganglia when VZV-specific T-cell immunity is decreased because of aging or immunosuppression. In the present study, we developed HZ DNA vaccine candidates encoding VZV proteins and cytokine adjuvants, such as IL-7 and IL-33. We immunized C57BL/6 mice with DNA plasmids encoding VZV glycoprotein E (gE), immediate early (IE) 63, or IE62 proteins and found that robust VZV protein-specific T-cell responses were elicited by HZ DNA vaccination. Co-administration of DNA plasmids encoding IL-7 or IL-33 in HZ DNA vaccination significantly enhanced the magnitude of VZV protein-specific T-cell responses. Protective immunity elicited by HZ DNA vaccination was proven by challenge experiments with a surrogate virus, vaccinia virus expressing gE (VV-gE). A single dose of HZ DNA vaccine strongly boosted gE-specific T-cell responses in mice with a history of previous infection by VV-gE. Thus, HZ DNA vaccines with IL-7 and IL-33 adjuvants strongly elicit protective immunity. | - |
dc.language | English | - |
dc.publisher | Korea Society for Immunology : Korean Society of Biological Response Modifiers | - |
dc.relation.isPartOf | IMMUNE NETWORK | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Herpes Zoster DNA Vaccines with IL-7 and IL-33 Molecular Adjuvants Elicit Protective T Cell Immunity | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학교실) | - |
dc.contributor.googleauthor | A Reum Kim | - |
dc.contributor.googleauthor | Junsik Park | - |
dc.contributor.googleauthor | Jong Hoon Kim | - |
dc.contributor.googleauthor | Jeong-Eun Kwak | - |
dc.contributor.googleauthor | Youngran Cho | - |
dc.contributor.googleauthor | Hyojin Lee | - |
dc.contributor.googleauthor | Moonsup Jeong | - |
dc.contributor.googleauthor | Su-Hyung Park | - |
dc.contributor.googleauthor | Eui-Cheol Shin | - |
dc.identifier.doi | 10.4110/in.2018.18.e38 | - |
dc.contributor.localId | A05233 | - |
dc.relation.journalcode | J01033 | - |
dc.identifier.eissn | 2092-6685 | - |
dc.identifier.pmid | 30402333 | - |
dc.subject.keyword | DNA vaccines | - |
dc.subject.keyword | Herpes zoster | - |
dc.subject.keyword | IL-33 | - |
dc.subject.keyword | IL-7 | - |
dc.subject.keyword | T-cells | - |
dc.contributor.alternativeName | Kim, Jong Hoon | - |
dc.contributor.affiliatedAuthor | 김종훈 | - |
dc.citation.volume | 18 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | e38 | - |
dc.identifier.bibliographicCitation | IMMUNE NETWORK, Vol.18(5) : e38, 2018-10 | - |
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