Cited 4 times in
PAX2, PAX8, and PR are correlated with ovarian seromucinous borderline tumor with endometriosis
DC Field | Value | Language |
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dc.contributor.author | 신은아 | - |
dc.date.accessioned | 2022-07-08T03:20:51Z | - |
dc.date.available | 2022-07-08T03:20:51Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188800 | - |
dc.description.abstract | Background: Ovarian "seromucinous carcinoma" has been recently removed in 2020 5th Edition of WHO classification of Female Genital Tumors and is considered as a subtype of endometrioid carcinoma with mucinous differentiation, while "seromucinous borderline tumor" remains and exists as a distinct entity. Both diseases may be considered as no more same lineage. However, ovarian seromucinous borderline tumor (SMBT) is also one of the endometriosis-related neoplasm of ovary similar to endometrioid tumor, featuring that about 50% of ovarian SMBTs combine endometriosis. The present study was aimed to investigate whether the ovarian SMBTs are different in clinical features and molecular patterns, according to the presence of combined endometriosis. Results: There were no statistical differences in clinical findings between two groups. There was also no significant difference in pregnancy outcomes and recurrence between two groups. In immunohistochemical patterns, there was a statistically significant difference in PAX2 and PAX8 expression between in ovarian SMBT with or without endometriosis (P = 0.016, P < 0.001). Only a few cases of ovarian SMBT with endometriosis showed expression of PAX2 and conversely, most of the cases showed expression of PAX8. PR positivity was more prominent in ovarian SMBT with endometriosis than without endometriosis (P = 0.018), although there was no difference in positive ER expression. There were no statistical differences in WT1, CK20 and CDX2 expressions between two groups. Conclusions: Ovarian SMBT with endometriosis did not clinically differ from that without endometriosis. However, the molecular patterns were different between two groups and ovarian SMBT with endometriosis is close to endometrioid tumor types unlike SMBT without endometriosis. Further, a direct comparison study between seromucinous borderline tumor and endometrioid borderline tumor is needed with a gene profiling study to prove their relationship. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | JOURNAL OF OVARIAN RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Carcinoma, Endometrioid* | - |
dc.subject.MESH | Carcinoma, Ovarian Epithelial | - |
dc.subject.MESH | Endometriosis* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genital Neoplasms, Female* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ovarian Neoplasms* / pathology | - |
dc.subject.MESH | PAX2 Transcription Factor | - |
dc.subject.MESH | PAX8 Transcription Factor | - |
dc.title | PAX2, PAX8, and PR are correlated with ovarian seromucinous borderline tumor with endometriosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Bo Seong Yun | - |
dc.contributor.googleauthor | Seyeon Won | - |
dc.contributor.googleauthor | Ju-Hyun Kim | - |
dc.contributor.googleauthor | Nara Lee | - |
dc.contributor.googleauthor | Miseon Kim | - |
dc.contributor.googleauthor | Mi Kyoung Kim | - |
dc.contributor.googleauthor | Mi-La Kim | - |
dc.contributor.googleauthor | Yong Wook Jung | - |
dc.contributor.googleauthor | Ji Young Kim | - |
dc.contributor.googleauthor | Seok Ju Seong | - |
dc.contributor.googleauthor | Eunah Shin | - |
dc.identifier.doi | 10.1186/s13048-022-00975-5 | - |
dc.contributor.localId | A05876 | - |
dc.relation.journalcode | J04213 | - |
dc.identifier.eissn | 1757-2215 | - |
dc.identifier.pmid | 35387670 | - |
dc.subject.keyword | Borderline tumor | - |
dc.subject.keyword | Endometrioid | - |
dc.subject.keyword | Endometriosis | - |
dc.subject.keyword | PAX2 | - |
dc.subject.keyword | PAX8 | - |
dc.subject.keyword | PR | - |
dc.subject.keyword | Seromucinous | - |
dc.contributor.alternativeName | Shin, Eunah | - |
dc.contributor.affiliatedAuthor | 신은아 | - |
dc.citation.volume | 15 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 41 | - |
dc.identifier.bibliographicCitation | JOURNAL OF OVARIAN RESEARCH, Vol.15(1) : 41, 2022-04 | - |
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