Cited 2 times in
Stroke and Systemic Thromboembolism according to CHA 2 DS 2-VASc Score in Contemporary Korean Patients with Atrial Fibrillation
DC Field | Value | Language |
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dc.contributor.author | 김태훈 | - |
dc.contributor.author | 정보영 | - |
dc.date.accessioned | 2022-07-08T03:19:01Z | - |
dc.date.available | 2022-07-08T03:19:01Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188780 | - |
dc.description.abstract | Purpose: The incidence of stroke and/or systemic thromboembolism (SSE) has not been properly evaluated in well-anticoagulated atrial fibrillation (AF) patients. This study investigated the incidence of SSE according to CHA2DS2-VASc score in contemporary well-anticoagulated Korean AF patients. Materials and methods: From the prospective multicenter COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation (CODE-AF) registry, we identified 9503 patients with non-valvular AF (mean age, 68±8 years; female 35.5%) enrolled between June 2016 and May 2020 with eligible follow-up visits. Stroke incidence in the CODE-AF registry was compared with that in an oral anticoagulant (OAC)-naïve AF cohort from the Korean National Health Insurance database. Results: The usage rates of OACs and antiplatelet agents were 73.5% (non-vitamin K OACs, 56.4%; warfarin, 17.1%) and 23.8%, respectively. During a mean follow-up period of 26.3±9.6 months, 163 (0.78 per 100 person-years) patients had SSE. The incidence rate (per 100 person-years) of SSE was 0.77 in the total population, 0.26 in low-risk patients [CHA2DS2-VASc score 0 (male) or 1 (female)], and 0.88 in high-risk patients (CHA2DS2-VASc score ≥2). Contemporary AF patients had a stroke rate that was about one-fifth the stroke rate reported in a Korean OAC-naïve AF cohort. In this cohort, most risk factors for CHA2DS2-VASc score showed significant associations with SSE. Female sex was not associated with an increased risk of stroke/SSE in well-anticoagulated AF patients. Conclusion: Contemporary AF patients have a stroke rate about one-fifth that in OAC-naïve AF patients and exhibit different stroke risk factors. Study registration: ClinicalTrials.gov (NCT02786095). | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Atrial Fibrillation* / complications | - |
dc.subject.MESH | Atrial Fibrillation* / drug therapy | - |
dc.subject.MESH | Atrial Fibrillation* / epidemiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Stroke* / etiology | - |
dc.subject.MESH | Thromboembolism* / epidemiology | - |
dc.subject.MESH | Thromboembolism* / etiology | - |
dc.subject.MESH | Thromboembolism* / prevention & control | - |
dc.title | Stroke and Systemic Thromboembolism according to CHA 2 DS 2-VASc Score in Contemporary Korean Patients with Atrial Fibrillation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Kyung Bae Lee | - |
dc.contributor.googleauthor | Tae-Hoon Kim | - |
dc.contributor.googleauthor | Junbeom Park | - |
dc.contributor.googleauthor | Jin-Kyu Park | - |
dc.contributor.googleauthor | Ki-Woon Kang | - |
dc.contributor.googleauthor | Jun Kim | - |
dc.contributor.googleauthor | Hyung Wook Park | - |
dc.contributor.googleauthor | Eue-Keun Choi | - |
dc.contributor.googleauthor | Jin-Bae Kim | - |
dc.contributor.googleauthor | Young Soo Lee | - |
dc.contributor.googleauthor | Jaemin Shim | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.identifier.doi | 10.3349/ymj.2022.63.4.317 | - |
dc.contributor.localId | A01085 | - |
dc.contributor.localId | A03609 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 35352882 | - |
dc.subject.keyword | Atrial fibrillation | - |
dc.subject.keyword | embolism | - |
dc.subject.keyword | risk | - |
dc.subject.keyword | stroke | - |
dc.contributor.alternativeName | Kim, Tae-Hoon | - |
dc.contributor.affiliatedAuthor | 김태훈 | - |
dc.contributor.affiliatedAuthor | 정보영 | - |
dc.citation.volume | 63 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 317 | - |
dc.citation.endPage | 324 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.63(4) : 317-324, 2022-04 | - |
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