Cited 31 times in
Human adipose mesenchymal stem cells modulate inflammation and angiogenesis through exosomes
DC Field | Value | Language |
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dc.contributor.author | 김신영 | - |
dc.date.accessioned | 2022-07-08T03:14:57Z | - |
dc.date.available | 2022-07-08T03:14:57Z | - |
dc.date.issued | 2022-02 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188741 | - |
dc.description.abstract | Stem cell-derived exosomes are efficient and safe therapeutic tools for transferring endogenous biological cargo or functional biomolecules for regenerative medicine. The regulation of inflammation and angiogenesis plays a pivotal role in wound healing and tissue regeneration. The purpose of this study was to investigate the anti-inflammatory and pro-angiogenic roles of human adipose mesenchymal stem cell-derived exosomes, focusing on the underlying mechanisms. Exosomes inhibited LPS-induced inflammation by activating ROCK1 and PTEN expression. Moreover, microRNAs (miR-132 and miR-146a) released from exosomes upregulated the expression of pro-angiogenic genes and promoted proliferation activity and tube formation in human umbilical vein endothelial cells. Exosomal effects were verified using ROCK1/PTEN inhibitors for anti-inflammation and miR-132/miR-146a inhibitors for pro-angiogenesis. Our findings suggest that exosomes exert anti-inflammatory effects by targeting the ROCK1/PTEN pathway and exhibit pro-angiogenic effects via delivery of miR-132 and miR-146a. Taken together, these results suggest that exosomes may be promising therapeutic candidates for curing diseases involved in inflammation and angiogenesis. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adipose Tissue / metabolism* | - |
dc.subject.MESH | Exosomes / metabolism* | - |
dc.subject.MESH | Human Umbilical Vein Endothelial Cells / metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammation / metabolism | - |
dc.subject.MESH | Mesenchymal Stem Cells / metabolism* | - |
dc.subject.MESH | Neovascularization, Physiologic* | - |
dc.title | Human adipose mesenchymal stem cells modulate inflammation and angiogenesis through exosomes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | June Seok Heo | - |
dc.contributor.googleauthor | Sinyoung Kim | - |
dc.identifier.doi | 10.1038/s41598-022-06824-1 | - |
dc.contributor.localId | A00675 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 35177768 | - |
dc.contributor.alternativeName | Kim, Sin Young | - |
dc.contributor.affiliatedAuthor | 김신영 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 2776 | - |
dc.citation.endPage | 2776 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.12(1) : 2776-2776, 2022-02 | - |
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