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Impact of Valve Culture Positivity on Prognosis in Patients with Infective Endocarditis Who Underwent Valve Surgery

DC Field Value Language
dc.contributor.author구남수-
dc.contributor.author김정호-
dc.contributor.author김진남-
dc.contributor.author백예지-
dc.contributor.author안진영-
dc.contributor.author염준섭-
dc.contributor.author이기현-
dc.contributor.author이세주-
dc.contributor.author이승현-
dc.contributor.author이은화-
dc.contributor.author정수진-
dc.contributor.author최준용-
dc.date.accessioned2022-07-08T03:14:12Z-
dc.date.available2022-07-08T03:14:12Z-
dc.date.issued2022-06-
dc.identifier.issn2193-8229-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188735-
dc.description.abstractIntroduction: Infective endocarditis (IE) is a severe and fatal infection with high in-hospital and overall mortality rates of approximately up to 30%. Valve culture positivity was associated with in-hospital mortality and postoperative complications; however, few studies have analyzed the relationship between valve cultures and overall mortality over a long observation period. This study aimed to compare the association of valve culture positivity with overall mortality in patients with IE who underwent valve surgery. Methods: A total of 416 IE patients admitted to a tertiary hospital in South Korea from November 2005 to August 2017 were retrospectively reviewed. A total of 202 IE patients who underwent valve surgery and valve culture were enrolled. The primary endpoint was long-term overall mortality. Kaplan-Meier curve and Cox proportional hazards model were used for survival analysis. Results: The median follow-up duration was 63 (interquartile range, 38-104) months. Valve cultures were positive in 22 (10.9%) patients. The overall mortality rate was 15.8% (32/202) and was significantly higher in valve culture-positive patients (36.4%, p = 0.011). Positive valve culture [hazard ratio (HR) 3.921, p = 0.002], Charlson Comorbidity Index (HR 1.181, p = 0.004), Coagulase-negative staphylococci (HR 4.233, p = 0.001), new-onset central nervous system complications (HR 3.689, p < 0.001), and new-onset heart failure (HR 4.331, p = 0.001) were significant risk factors for overall mortality. Conclusions: Valve culture positivity is a significant risk factor for long-term overall mortality in IE patients who underwent valve surgery. The importance of valve culture positivity needs to be re-evaluated, as the valve culture positivity rate increases with increasing early surgical intervention.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAdis-
dc.relation.isPartOfINFECTIOUS DISEASES AND THERAPY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleImpact of Valve Culture Positivity on Prognosis in Patients with Infective Endocarditis Who Underwent Valve Surgery-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJinnam Kim-
dc.contributor.googleauthorJung Ho Kim-
dc.contributor.googleauthorHi Jae Lee-
dc.contributor.googleauthorSe Ju Lee-
dc.contributor.googleauthorKi Hyun Lee-
dc.contributor.googleauthorEun Hwa Lee-
dc.contributor.googleauthorYae Jee Baek-
dc.contributor.googleauthorJin Young Ahn-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorNam Su Ku-
dc.contributor.googleauthorSeung Hyun Lee-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorJoon-Sup Yeom-
dc.identifier.doi10.1007/s40121-022-00642-8-
dc.contributor.localIdA00189-
dc.contributor.localIdA00902-
dc.contributor.localIdA05112-
dc.contributor.localIdA05921-
dc.contributor.localIdA02267-
dc.contributor.localIdA02353-
dc.contributor.localIdA06174-
dc.contributor.localIdA05162-
dc.contributor.localIdA02935-
dc.contributor.localIdA06176-
dc.contributor.localIdA03638-
dc.contributor.localIdA04191-
dc.relation.journalcodeJ04212-
dc.identifier.eissn2193-6382-
dc.identifier.pmid35489001-
dc.subject.keywordEndocarditis-
dc.subject.keywordHeart valves-
dc.subject.keywordMortality-
dc.subject.keywordTissue culture.-
dc.contributor.alternativeNameKu, Nam Su-
dc.contributor.affiliatedAuthor구남수-
dc.contributor.affiliatedAuthor김정호-
dc.contributor.affiliatedAuthor김진남-
dc.contributor.affiliatedAuthor백예지-
dc.contributor.affiliatedAuthor안진영-
dc.contributor.affiliatedAuthor염준섭-
dc.contributor.affiliatedAuthor이기현-
dc.contributor.affiliatedAuthor이세주-
dc.contributor.affiliatedAuthor이승현-
dc.contributor.affiliatedAuthor이은화-
dc.contributor.affiliatedAuthor정수진-
dc.contributor.affiliatedAuthor최준용-
dc.citation.volume11-
dc.citation.number3-
dc.citation.startPage1253-
dc.citation.endPage1265-
dc.identifier.bibliographicCitationINFECTIOUS DISEASES AND THERAPY, Vol.11(3) : 1253-1265, 2022-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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