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Association between new-onset Parkinson's disease and suicide risk in South Korea: a nationwide cohort study

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dc.contributor.author박은철-
dc.contributor.author장석용-
dc.date.accessioned2022-07-08T03:13:47Z-
dc.date.available2022-07-08T03:13:47Z-
dc.date.issued2022-05-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188732-
dc.description.abstractBackground: Parkinson's disease (PD) is an increasingly common neurodegenerative disease in an aging society. Whether PD is associated with an increased suicide risk is unclear. Thus, we investigated the effect of new-onset PD on suicide. Methods: Using the National Health Insurance Service Senior Sample Cohort of South Korea, 17,143 incident PD patients and 17,143 risk set controls, matched by propensity score, were selected for follow-up. The incidence rate of suicide and 95% confidence interval (CI) were calculated based on a generalized linear model of the Poisson distribution. Effect sizes were expressed as hazard ratios (HRs) using the Cox proportional hazards model with a robust variance estimator that incorporated clustering within matched pairs. Results: The incidence rate of suicide was 206.7 cases per 100,000 person-years (95% CI, 172.8-246.9) among the PD cohort. Compared to the matched controls, patients with PD were 2.64 times (HR, 2.64; 95% CI, 1.31-5.30) more likely to commit suicide during the first 180 days of follow-up and 2.47 times (HR, 2.47; 95% CI, 1.42-4.28) within the first 365 days of follow-up. During the entire follow-up period, patients with PD were 2.26 times more likely to commit suicide than were their matched controls (HR, 2.26; 95% CI, 1.67-3.06). Conclusion: Our findings indicated an increased risk of suicide in patients with new-onset PD, regardless of the period after diagnosis. Incorporating mental health care with social and environmental interventions into primary care and PD-specialized care can help reduce suicide risk in people with PD, improving suicide prevention, identification, and risk assessment.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfBMC PSYCHIATRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHCohort Studies-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHNeurodegenerative Diseases*-
dc.subject.MESHParkinson Disease* / diagnosis-
dc.subject.MESHParkinson Disease* / epidemiology-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.subject.MESHRisk Factors-
dc.subject.MESHSuicide*-
dc.titleAssociation between new-onset Parkinson's disease and suicide risk in South Korea: a nationwide cohort study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine (예방의학교실)-
dc.contributor.googleauthorSung Hoon Jeong-
dc.contributor.googleauthorSeung Hoon Kim-
dc.contributor.googleauthorDoo Woong Lee-
dc.contributor.googleauthorEun-Cheol Park-
dc.contributor.googleauthorSuk-Yong Jang-
dc.identifier.doi10.1186/s12888-022-03990-4-
dc.contributor.localIdA01618-
dc.contributor.localIdA03432-
dc.relation.journalcodeJ00372-
dc.identifier.eissn1471-244X-
dc.identifier.pmid35581575-
dc.subject.keywordDepression-
dc.subject.keywordParkinson’s disease-
dc.subject.keywordPsychiatric disorder-
dc.subject.keywordRisk-
dc.subject.keywordSuicide-
dc.contributor.alternativeNamePark, Eun-Chul-
dc.contributor.affiliatedAuthor박은철-
dc.contributor.affiliatedAuthor장석용-
dc.citation.volume22-
dc.citation.number1-
dc.citation.startPage341-
dc.identifier.bibliographicCitationBMC PSYCHIATRY, Vol.22(1) : 341, 2022-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

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