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Effect of Postoperative Radiotherapy after Primary Tumor Resection in De Novo Stage IV Breast Cancer: A Multicenter Retrospective Study (KROG 19-02)

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dc.contributor.author김용배-
dc.contributor.author이익재-
dc.date.accessioned2022-07-08T03:06:14Z-
dc.date.available2022-07-08T03:06:14Z-
dc.date.issued2022-04-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188664-
dc.description.abstractPurpose: This study aimed to investigate the impact of postoperative radiotherapy (PORT) in de novo metastatic breast cancer (dnMBC) patients undergoing planned primary tumor resection (PTR) and to identify the subgroup of patients who would most benefit from PORT. Materials and methods: This study enrolled 426 patients with dnMBC administered PTR alone or with PORT. The primary and secondary outcomes were overall and progression-free survival (OS and PFS), respectively. Results: The median follow-up time was 53.7 months (range, 3.1 to 194.4). The 5-year OS and PFS rates were 73.2% and 32.0%, respectively. For OS, clinical T3/4 category, triple-negative breast cancer (TNBC), postoperative chemotherapy alone were significantly poor prognostic factors, and administration of PORT failed to show its significance. Regarding PFS, PORT was a favorable prognostic factor (hazard ratio, 0.64; 95% confidence interval, 0.50 to 0.82; p < 0.001), in addition to T1/2 category, ≤ 5 metastases, and non-TNBC. According to the multivariate analyses of OS in the PORT group, we divided the patients into three groups (group 1, T1/2 and non-TNBC [n=193]; group 2, T3/4 and non-TNBC [n=171]; and group 3, TNBC [n=49]), and evaluated the effect of PORT. Although PORT had no significance for OS in all subgroups, it was a significant factor for good prognosis regarding PFS in groups 1 and 2, not in group 3. Conclusion: PORT was associated with a significantly better PFS in patients with dnMBC who underwent PTR. Patients with clinical T1/2 category and non-TNBC benefited most from PORT, while those with TNBC showed little benefit.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish, Korean-
dc.publisherOfficial journal of Korean Cancer Association-
dc.relation.isPartOfCANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHHumans-
dc.subject.MESHPrognosis-
dc.subject.MESHProgression-Free Survival-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTriple Negative Breast Neoplasms* / radiotherapy-
dc.subject.MESHTriple Negative Breast Neoplasms* / surgery-
dc.titleEffect of Postoperative Radiotherapy after Primary Tumor Resection in De Novo Stage IV Breast Cancer: A Multicenter Retrospective Study (KROG 19-02)-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorYeon Joo Kim-
dc.contributor.googleauthorYeon-Joo Kim-
dc.contributor.googleauthorYong Bae Kim-
dc.contributor.googleauthorIk Jae Lee-
dc.contributor.googleauthorJeanny Kwon-
dc.contributor.googleauthorKyubo Kim-
dc.contributor.googleauthorJihye Cha-
dc.contributor.googleauthorMyungsoo Kim-
dc.contributor.googleauthorIn Young Jo-
dc.contributor.googleauthorJung Hoon Kim-
dc.contributor.googleauthorJaehyeon Park-
dc.contributor.googleauthorJin Hee Kim-
dc.contributor.googleauthorJuree Kim-
dc.contributor.googleauthorKyung Hwan Shin-
dc.contributor.googleauthorSu Ssan Kim-
dc.identifier.doi10.4143/crt.2021.632-
dc.contributor.localIdA00744-
dc.contributor.localIdA03055-
dc.relation.journalcodeJ00453-
dc.identifier.eissn2005-9256-
dc.identifier.pmid34265890-
dc.subject.keywordBreast surgery-
dc.subject.keywordPostoperative radiotherapy-
dc.subject.keywordStage IV breast cancer-
dc.subject.keywordSurvival-
dc.contributor.alternativeNameKim, Yong Bae-
dc.contributor.affiliatedAuthor김용배-
dc.contributor.affiliatedAuthor이익재-
dc.citation.volume54-
dc.citation.number2-
dc.citation.startPage478-
dc.citation.endPage487-
dc.identifier.bibliographicCitationCANCER RESEARCH AND TREATMENT, Vol.54(2) : 478-487, 2022-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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