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Cited 3 times in

Preclinical evaluation of endoscopic placement of a steroid-eluting metal stent in an in vivo porcine benign biliary stricture model

DC Field Value Language
dc.contributor.author남지해-
dc.contributor.author이동기-
dc.contributor.author장성일-
dc.contributor.author조재희-
dc.contributor.author황성순-
dc.contributor.author도민영-
dc.date.accessioned2022-07-08T03:04:54Z-
dc.date.available2022-07-08T03:04:54Z-
dc.date.issued2022-05-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188653-
dc.description.abstractTreatment of benign biliary strictures (BBS) using fully covered self-expandable metal stents (FCSEMS) has a high success rate, but recurrence can occur. Corticosteroids may be useful based on their anti-fibrotic and anti-inflammatory effects. We investigated the safety and efficacy of corticosteroid-eluting FCSEMS in an animal model. BBSs were created by radiofrequency ablation in 12 mini-pigs. Four weeks later, FCSEMS coated with 0 mg (control), 15 mg (steroid 1 × group), or 30 mg (steroid 2 × group) triamcinolone were inserted endoscopically. The in vitro drug release assay revealed that the optimal stent had 15 mg of triamcinolone and a hydrophilic membrane. No transmural necrosis or perforation occurred in any animal. Fibrous wall thickness tended to decrease macroscopically and microscopically in a triamcinolone dose-dependent manner (control vs. steroid 2 × group: 773.1 vs. 468.5 µm, P = 0.037). Thickness also decreased over time in the steroid 2 × group (3 days vs. 4 weeks: 907.9 vs. 468.5 µm, P = 0.025). Blood parameters tended to improve after stent insertion. In a porcine BBS model, steroid-eluting FCSEMS showed potential as a safe and effective treatment modality to reduce fibrotic tissue. Studies are required to confirm their safety and efficacy in humans with refractory BBS.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHCholangiopancreatography, Endoscopic Retrograde*-
dc.subject.MESHCholestasis* / therapy-
dc.subject.MESHConstriction, Pathologic / surgery-
dc.subject.MESHDevice Removal-
dc.subject.MESHStents / adverse effects-
dc.subject.MESHSteroids-
dc.subject.MESHSwine-
dc.subject.MESHSwine, Miniature-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHTriamcinolone-
dc.titlePreclinical evaluation of endoscopic placement of a steroid-eluting metal stent in an in vivo porcine benign biliary stricture model-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorSung Ill Jang-
dc.contributor.googleauthorSungsoon Fang-
dc.contributor.googleauthorJi Hae Nahm-
dc.contributor.googleauthorJae Hee Cho-
dc.contributor.googleauthorMin Young Do-
dc.contributor.googleauthorSu Yeon Lee-
dc.contributor.googleauthorSeok Jeong-
dc.contributor.googleauthorDon Haeng Lee-
dc.contributor.googleauthorDong Ki Lee-
dc.identifier.doi10.1038/s41598-022-12957-0-
dc.contributor.localIdA05120-
dc.contributor.localIdA02723-
dc.contributor.localIdA03441-
dc.contributor.localIdA03902-
dc.contributor.localIdA05443-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid35614115-
dc.contributor.alternativeNameNahm, Ji Hae-
dc.contributor.affiliatedAuthor남지해-
dc.contributor.affiliatedAuthor이동기-
dc.contributor.affiliatedAuthor장성일-
dc.contributor.affiliatedAuthor조재희-
dc.contributor.affiliatedAuthor황성순-
dc.citation.volume12-
dc.citation.number1-
dc.citation.startPage8864-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.12(1) : 8864, 2022-05-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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