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Impact of preoperative laboratory frailty index on mortality and clinical outcomes in older surgical patients with cancer

 Yoonjoo Kim  ;  Kijun Song  ;  Chang Moo Kang  ;  Hyangkyu Lee 
 SCIENTIFIC REPORTS, Vol.12(1) : 9200, 2022-06 
Journal Title
Issue Date
Aged ; Frail Elderly ; Frailty* ; Geriatric Assessment / methods ; Humans ; Neoplasms* / surgery ; Prospective Studies ; Retrospective Studies
Frailty in older patients is associated with poor postoperative outcomes. The use of uncomplicated frailty measurement tools is preferred in busy clinical settings. Therefore, we validated the frailty index using routine laboratory data and the surgical outcomes of older patients with cancer who underwent cancer resection. We retrospectively analyzed 9015 patients aged 65 years and older who underwent cancer resection at a single tertiary hospital. Based on electronic-medical-record data regarding preoperative blood test results and vital signs, Laboratory Frailty Index (FI-Lab) scores were generated to measure preoperative frailty. The associations of FI-Lab with postoperative length of stay (LOS), readmission within 30 days, intensive care unit (ICU) admission within 30 days, and mortality were evaluated. The mean FI-Lab score of the 9015 patients was 0.20 ± 0.10. Increased FI-Lab scores (0.25-0.4; > 0.4) were associated with longer LOS, increased readmission within 30 days of surgery, ICU admission, and increased mortality, compared with FI-Lab scores < 0.25. The FI-Lab score, as a frailty indicator, was able to predict the risk of poor postoperative outcomes. Therefore, the FI-Lab is a potentially useful tool for assessing preoperative frailty in older patients with cancer in acute clinical setting.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
Kang, Chang Moo(강창무) ORCID logo https://orcid.org/0000-0002-5382-4658
Song, Ki Jun(송기준) ORCID logo https://orcid.org/0000-0003-2505-4112
Lee, Hyang Kyu(이향규) ORCID logo https://orcid.org/0000-0002-0821-6020
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