Continuing perioperative estrogen therapy does not increase venous thromboembolic events in transgender patients: a systematic review and meta-analysis

J Badreddine; M H Lee; K Mishra; R Pope; J Y Kim; S H Hong; S Gupta; J M Song; J I Shin; R A Ghayda

doi:10.26355/eurrev_202204_28488

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Continuing perioperative estrogen therapy does not increase venous thromboembolic events in transgender patients: a systematic review and meta-analysis

Authors: J Badreddine ; M H Lee ; K Mishra ; R Pope ; J Y Kim ; S H Hong ; S Gupta ; J M Song ; J I Shin ; R A Ghayda

Citation: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, Vol.26(7) : 2511-2517, 2022-04

Journal Title: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES

ISSN: 1128-3602

Issue Date: 2022-04

MeSH: Estrogens / adverse effects ; Female ; Hormone Replacement Therapy ; Humans ; Male ; Transgender Persons* ; Venous Thromboembolism* / chemically induced ; Venous Thromboembolism* / epidemiology ; Venous Thrombosis*

Abstract: Objective: The aim of this study is to compare the risk of venous thromboembolic events (VTE) between patients suspending and continuing estrogen therapy perioperatively, in male to female gender-affirming surgery (vaginoplasty).

Materials and methods: The authors conducted a systematic review and meta-analysis of existing research on male to female gender-affirming study, which compared the risk of VTE among the usage of estrogen perioperatively.

Results: A total of 209 studies were identified as potentially eligible among PubMed, Embase, and Cochrane library databases. Among the studies, 191 studies were excluded due to their abstract inappropriateness. Out of the remaining 18 studies, only 3 articles were eligible and were finally included. Meta-analysis was performed and showed odds ratio of 0.77 (95% CI: 0.04, 14.01).

Conclusions: Perioperative estrogen therapy does not increase VTE risk on male to female gender-affirming surgery. Therefore, estrogen therapy may be continued perioperatively in vaginoplasty. More prospective studies are needed.