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Tumor Genomic Testing for >4,000 Men with Metastatic Castration-resistant Prostate Cancer in the Phase III Trial PROfound (Olaparib)

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dc.contributor.author최영득-
dc.date.accessioned2022-05-09T17:23:15Z-
dc.date.available2022-05-09T17:23:15Z-
dc.date.issued2022-04-
dc.identifier.issn1078-0432-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188539-
dc.description.abstractPurpose: Successful implementation of genomic testing in clinical practice is critical for identification of men with metastatic castration-resistant prostate cancer (mCRPC) eligible for olaparib and future molecularly targeted therapies. Patients and methods: An investigational clinical trial assay, based on the FoundationOneCDx tissue test, was used to prospectively identify patients with qualifying homologous recombination repair gene alterations in the phase III PROfound study. Evaluation of next-generation sequencing (NGS) tissue test outcome against preanalytic parameters was performed to identify key factors influencing NGS result generation. Results: A total of 4,858 tissue samples from 4,047 patients were tested and reported centrally. NGS results were obtained in 58% (2,792/4,858) of samples (69% of patients). Of samples submitted, 83% were primary tumor samples (96% were archival and 4% newly obtained). Almost 17% were metastatic tumor samples (60% were archival and 33% newly obtained). NGS results were generated more frequently from newly obtained compared with archival samples (63.9% vs. 56.9%) and metastatic compared with primary samples (63.9% vs. 56.2%). Although generation of an NGS result declined with increasing sample age, approximately 50% of samples ages >10 years generated results. While higher tumor content and DNA yield resulted in greater success in obtaining NGS results, other factors, including selection and preservation of samples, may also have had an impact. Conclusions: The PROfound study shows that tissue testing to identify homologous recombination repair alterations is feasible and that high-quality tumor tissue samples are key to obtaining NGS results and identifying patients with mCRPC who may benefit from olaparib treatment.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican Association for Cancer Research-
dc.relation.isPartOfCLINICAL CANCER RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHGenetic Testing-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHPhthalazines / therapeutic use-
dc.subject.MESHPiperazines / therapeutic use-
dc.subject.MESHProstatic Neoplasms, Castration-Resistant* / drug therapy-
dc.subject.MESHProstatic Neoplasms, Castration-Resistant* / genetics-
dc.subject.MESHProstatic Neoplasms, Castration-Resistant* / pathology-
dc.titleTumor Genomic Testing for >4,000 Men with Metastatic Castration-resistant Prostate Cancer in the Phase III Trial PROfound (Olaparib)-
dc.title.alternativeTumor Genomic Testing for >4,000 Men with Metastatic Castration-resistant Prostate Cancer in the Phase III Trial PROfound (Olaparib)-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨의학교실)-
dc.contributor.googleauthorMaha Hussain-
dc.contributor.googleauthorClaire Corcoran-
dc.contributor.googleauthorCaroline Sibilla-
dc.contributor.googleauthorKarim Fizazi-
dc.contributor.googleauthorFred Saad-
dc.contributor.googleauthorNeal Shore-
dc.contributor.googleauthorShahneen Sandhu-
dc.contributor.googleauthorJoaquin Mateo-
dc.contributor.googleauthorDavid Olmos-
dc.contributor.googleauthorNiven Mehra-
dc.contributor.googleauthorMichael P Kolinsky-
dc.contributor.googleauthorGuilhem Roubaud-
dc.contributor.googleauthorMustafa Özgüroǧlu-
dc.contributor.googleauthorNobuaki Matsubara-
dc.contributor.googleauthorCraig Gedye-
dc.contributor.googleauthorYoung Deuk Choi-
dc.contributor.googleauthorCharles Padua-
dc.contributor.googleauthorAlexander Kohlmann-
dc.contributor.googleauthorRobert Huisden-
dc.contributor.googleauthorJulia A Elvin-
dc.contributor.googleauthorJinyu Kang-
dc.contributor.googleauthorCarrie A Adelman-
dc.contributor.googleauthorAllison Allen-
dc.contributor.googleauthorChristian Poehlein-
dc.contributor.googleauthorJohann de Bono-
dc.identifier.doi10.1158/1078-0432.CCR-21-3940-
dc.contributor.localIdA04111-
dc.relation.journalcodeJ00564-
dc.identifier.pmid35091440-
dc.identifier.urlhttps://aacrjournals.org/clincancerres/article/28/8/1518/694173/Tumor-Genomic-Testing-for-gt-4-000-Men-with-
dc.contributor.alternativeNameChoi, Young Deuk-
dc.contributor.affiliatedAuthor최영득-
dc.citation.volume28-
dc.citation.number8-
dc.citation.startPage1518-
dc.citation.endPage1530-
dc.identifier.bibliographicCitationCLINICAL CANCER RESEARCH, Vol.28(8) : 1518-1530, 2022-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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