Cited 5 times in
Insulin Requirement and Complications Associated With Serum C-Peptide Decline in Patients With Type 1 Diabetes Mellitus During 15 Years After Diagnosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권아름 | - |
dc.contributor.author | 김호성 | - |
dc.contributor.author | 서정환 | - |
dc.contributor.author | 송경철 | - |
dc.contributor.author | 이명섭 | - |
dc.contributor.author | 채현욱 | - |
dc.contributor.author | 최한샘 | - |
dc.date.accessioned | 2022-05-09T17:18:48Z | - |
dc.date.available | 2022-05-09T17:18:48Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188504 | - |
dc.description.abstract | Objective: C-peptide is conventionally used in assessing pancreatic function in patients with diabetes mellitus. The clinical significance of this molecule during the course of type 1 diabetes mellitus (T1DM) has been recently revisited. This study aimed to investigate the natural course of C-peptide in T1DM patients over the period of 15 years and analyze the association between the residual C-peptide and diabetes complications. Methods: This retrospective study included a total of 234 children and adolescents with T1DM. Patient data including sex, age at diagnosis, anthropometric measures, daily insulin dose, serum HbA1c, post-prandial serum C-peptide levels, lipid profiles, and diabetic complications at the time of diagnosis and 1, 3, 5, 10, and 15 years after diagnosis were retrospectively collected. Results: Among the 234 patients, 101 were men and 133 were women, and the mean patient age at initial diagnosis was 8.3 years. Serum C-peptide decreased constantly since the initial diagnosis, and showed a significant decline at 3 years after diagnosis. At 15 years after diagnosis, only 26.2% of patients had detectable serum C-peptide levels. The subgroup with older patients and patients with higher BMI standard deviation score showed higher mean serum C-peptide, but the group-by-time results were not significant, respectively. Patients with higher serum C-peptide required lower doses of insulin and had fewer events of diabetic ketoacidosis. Conclusion: Serum C-peptide decreased consistently since diagnosis of T1DM, showing a significant decline after 3 years. Patients with residual C-peptide required a lower dose of insulin and had a lower risk for diabetic ketoacidosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Frontiers Research | - |
dc.relation.isPartOf | FRONTIERS IN ENDOCRINOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Insulin Requirement and Complications Associated With Serum C-Peptide Decline in Patients With Type 1 Diabetes Mellitus During 15 Years After Diagnosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Junghwan Suh | - |
dc.contributor.googleauthor | Hae In Lee | - |
dc.contributor.googleauthor | Myeongseob Lee | - |
dc.contributor.googleauthor | Kyungchul Song | - |
dc.contributor.googleauthor | Han Saem Choi | - |
dc.contributor.googleauthor | Ahreum Kwon | - |
dc.contributor.googleauthor | Ho-Seong Kim | - |
dc.contributor.googleauthor | Hyun Wook Chae | - |
dc.identifier.doi | 10.3389/fendo.2022.869204 | - |
dc.contributor.localId | A00228 | - |
dc.contributor.localId | A01184 | - |
dc.contributor.localId | A05629 | - |
dc.contributor.localId | A06013 | - |
dc.contributor.localId | A06265 | - |
dc.contributor.localId | A04026 | - |
dc.relation.journalcode | J03412 | - |
dc.identifier.eissn | 1664-2392 | - |
dc.contributor.alternativeName | Kwon, Ah Reum | - |
dc.contributor.affiliatedAuthor | 권아름 | - |
dc.contributor.affiliatedAuthor | 김호성 | - |
dc.contributor.affiliatedAuthor | 서정환 | - |
dc.contributor.affiliatedAuthor | 송경철 | - |
dc.contributor.affiliatedAuthor | 이명섭 | - |
dc.contributor.affiliatedAuthor | 채현욱 | - |
dc.citation.volume | 13 | - |
dc.citation.startPage | 869203 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN ENDOCRINOLOGY, Vol.13 : 869203, 2022-04 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.