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Insulin Requirement and Complications Associated With Serum C-Peptide Decline in Patients With Type 1 Diabetes Mellitus During 15 Years After Diagnosis

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dc.contributor.author권아름-
dc.contributor.author김호성-
dc.contributor.author서정환-
dc.contributor.author송경철-
dc.contributor.author이명섭-
dc.contributor.author채현욱-
dc.contributor.author최한샘-
dc.date.accessioned2022-05-09T17:18:48Z-
dc.date.available2022-05-09T17:18:48Z-
dc.date.issued2022-04-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188504-
dc.description.abstractObjective: C-peptide is conventionally used in assessing pancreatic function in patients with diabetes mellitus. The clinical significance of this molecule during the course of type 1 diabetes mellitus (T1DM) has been recently revisited. This study aimed to investigate the natural course of C-peptide in T1DM patients over the period of 15 years and analyze the association between the residual C-peptide and diabetes complications. Methods: This retrospective study included a total of 234 children and adolescents with T1DM. Patient data including sex, age at diagnosis, anthropometric measures, daily insulin dose, serum HbA1c, post-prandial serum C-peptide levels, lipid profiles, and diabetic complications at the time of diagnosis and 1, 3, 5, 10, and 15 years after diagnosis were retrospectively collected. Results: Among the 234 patients, 101 were men and 133 were women, and the mean patient age at initial diagnosis was 8.3 years. Serum C-peptide decreased constantly since the initial diagnosis, and showed a significant decline at 3 years after diagnosis. At 15 years after diagnosis, only 26.2% of patients had detectable serum C-peptide levels. The subgroup with older patients and patients with higher BMI standard deviation score showed higher mean serum C-peptide, but the group-by-time results were not significant, respectively. Patients with higher serum C-peptide required lower doses of insulin and had fewer events of diabetic ketoacidosis. Conclusion: Serum C-peptide decreased consistently since diagnosis of T1DM, showing a significant decline after 3 years. Patients with residual C-peptide required a lower dose of insulin and had a lower risk for diabetic ketoacidosis.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherFrontiers Research-
dc.relation.isPartOfFRONTIERS IN ENDOCRINOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleInsulin Requirement and Complications Associated With Serum C-Peptide Decline in Patients With Type 1 Diabetes Mellitus During 15 Years After Diagnosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학교실)-
dc.contributor.googleauthorJunghwan Suh-
dc.contributor.googleauthorHae In Lee-
dc.contributor.googleauthorMyeongseob Lee-
dc.contributor.googleauthorKyungchul Song-
dc.contributor.googleauthorHan Saem Choi-
dc.contributor.googleauthorAhreum Kwon-
dc.contributor.googleauthorHo-Seong Kim-
dc.contributor.googleauthorHyun Wook Chae-
dc.identifier.doi10.3389/fendo.2022.869204-
dc.contributor.localIdA00228-
dc.contributor.localIdA01184-
dc.contributor.localIdA05629-
dc.contributor.localIdA06013-
dc.contributor.localIdA06265-
dc.contributor.localIdA04026-
dc.relation.journalcodeJ03412-
dc.identifier.eissn1664-2392-
dc.contributor.alternativeNameKwon, Ah Reum-
dc.contributor.affiliatedAuthor권아름-
dc.contributor.affiliatedAuthor김호성-
dc.contributor.affiliatedAuthor서정환-
dc.contributor.affiliatedAuthor송경철-
dc.contributor.affiliatedAuthor이명섭-
dc.contributor.affiliatedAuthor채현욱-
dc.citation.volume13-
dc.citation.startPage869203-
dc.identifier.bibliographicCitationFRONTIERS IN ENDOCRINOLOGY, Vol.13 : 869203, 2022-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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